Flibanserin instructions for use, how to take?

Flibanserin is a pharmacological agent specifically developed for the treatment of distinct sexual dysfunctions in women. Its designated purpose is to address a condition known as Hypoactive Sexual Desire Disorder (HSDD), which is characterized by a clinically significant reduction or complete absence of sexual fantasies and desire for sexual activity.

The medication's mechanism of action is not based on hormonal stimulation; instead, it functions as a neurotransmitter modulator within the brain. Its primary role is to restore the appropriate balance of specific chemical compounds (neurotransmitters) that are directly involved in regulating sexual interest, arousal, and satisfaction. Consequently, it addresses the root cause of the issue at a biochemical level in the brain.

Composition of the Medication

The therapeutic effect is driven by flibanserin, the active pharmaceutical ingredient. The standard therapeutic dosage contained within a single tablet is 100 mg.

In addition to the main component, the tablet formulation includes several excipients (inactive ingredients). These auxiliary substances do not possess any pharmacological activity themselves but perform critically important technological functions: they ensure the physical stability of the tablet, protect the active ingredient from degradation, facilitate its correct and uniform release and absorption in the gastrointestinal tract, and make the medication convenient for patient use.

Spectrum of Indications for Use

Flibanserin has a narrow and clearly defined set of indications. It is prescribed exclusively for women who are in the premenopausal stage (i.e., before the onset of menopause) and have a formal diagnosis of Hypoactive Sexual Desire Disorder (HSDD).

It is crucial to understand that the medication is not intended for just any decrease in libido, but only for what qualifies as a "disorder." This means the lack of desire must be persistent and cause the woman significant psychological distress, stress, or substantially impair interpersonal relationships and overall quality of life. Flibanserin aims to re-establish the disrupted chemical balance in the brain centers responsible for libido.

Administration and Dosage Guidelines

To achieve the optimal therapeutic effect and minimize risks, it is imperative to adhere strictly to the administration instructions.

• Dosage: The standard recommended dose is one tablet (100 mg). This dose is taken once per day.

• Time of Administration: The medication must be taken at bedtime. This directive is a mandatory safety precaution. Taking it during the daytime significantly increases the risk of adverse effects, particularly dizziness, somnolence (sleepiness), and a sudden drop in blood pressure (hypotension), which can lead to fainting.

• Duration of Treatment: Flibanserin is not an "on-demand" or instant-action drug. The first positive changes usually become noticeable only after 4 to 6 weeks of consistent daily intake. Achieving the maximum and stable therapeutic effect may require 8 to 12 weeks (2-3 months) of an uninterrupted course.

• Missed Dose: If you forget to take your tablet at bedtime, you must not compensate by taking a double dose the next day or taking the missed dose in the morning. Simply skip that dose and take your next standard dose at your usual time in the evening.

Absolute Contraindications

There is a range of conditions and circumstances under which taking Flibanserin is strictly prohibited due to a high risk of serious harm to health:

1. Alcohol Consumption: The concurrent use of Flibanserin and any alcoholic beverages is absolutely contraindicated. Their interaction can provoke severe hypotension (a drastic drop in blood pressure) and syncope (fainting or loss of consciousness).

2. Drug Interactions: It is forbidden to take the medication simultaneously with drugs that are moderate or strong inhibitors of the CYP3A4 enzyme. This enzyme is responsible for metabolizing Flibanserin. Blocking it (e.g., with certain antibiotics, antifungal medications, or even grapefruit juice) leads to a dangerous accumulation of the drug in the bloodstream.

3. Liver Disease: Any serious or moderate impairment of liver function (hepatic impairment) is a contraindication, as the liver is primarily responsible for clearing the drug from the body.

4. Allergy: A known individual hypersensitivity or allergic reaction to flibanserin or any of the inactive ingredients in the tablet.

Potential Side Effects

Like any medication, Flibanserin can cause undesirable reactions.

Most Common Side Effects (usually mild to moderate):

• Dizziness (especially when changing posture).

• Nausea (a feeling of discomfort in the stomach).

• Somnolence (sleepiness or excessive fatigue).

• Xerostomia (a sensation of dryness in the mouth).

Rare but Serious Adverse Reactions:

• Severe Hypotension: A significant drop in blood pressure.

• Syncope: A sudden, brief loss of consciousness (fainting).

In the event of any alarming or serious symptoms, particularly those related to a drop in blood pressure or loss of consciousness, it is necessary to immediately stop taking the medication and seek emergency medical attention.

Important Precautions and Special Warnings

• Alcohol: To reiterate—combining Flibanserin with alcohol is strictly forbidden for the entire duration of the treatment course.

• Drug Interactions: Before initiating therapy, it is vitally important to inform your physician of absolutely all medications, vitamins, supplements, and herbal products you are currently taking to rule out dangerous interactions.

• Operating Transport: Due to the high probability of drowsiness, dizziness, and slowed reaction times (especially in the hours after taking it), it is strongly advised to refrain from driving a car or operating complex and potentially hazardous machinery. This is especially true at the beginning of treatment until you understand how the medication affects your body.

Availability and Acquisition

Flibanserin can be purchased in Ukraine by using the services of online pharmacies or specialized e-commerce stores that offer pharmaceutical products. Most such services provide delivery throughout the country. Placing an order online typically ensures complete confidentiality of the purchase and prompt receipt of the required medication.

Flibanserin is regarded as a reliable therapeutic solution that helps women with diagnosed HSDD regain self-confidence and restore harmony in their intimate lives, thereby significantly improving their overall quality of life.