ASSURANS

What is ASSURANS?

ASSURANS is a highly effective medicinal product that belongs to the pharmacotherapeutic group of vasodilators used for the treatment of pulmonary arterial hypertension. This medication is designed to normalize hemodynamics in the vessels of the pulmonary circulation and improve the overall physical condition of patients. This product is available in the form of film-coated tablets intended for oral use. The manufacturer of the medicinal product ensures high quality control at all stages of production, which guarantees compliance with international pharmaceutical standards.

The main action of the medication is aimed at reducing elevated pressure in the pulmonary arteries by selective relaxation of vascular smooth muscles. Thanks to this, the heart is able to pump blood through the lungs more efficiently, which significantly reduces the workload on the right ventricle. The drug is actively used in modern cardiology and pulmonology as a monotherapy or as part of combination treatment regimens. The optimally selected dosage form ensures stable release of the active substance and its high bioavailability in the human body.

Systematic intake of the medication allows to significantly increase patients' tolerance to physical activity and slow down the progression of the pathological process. The medicinal product has proven itself as a reliable element of long-term health support for individuals with severe vascular pathologies of the lungs. This pharmaceutical product must be prescribed exclusively by a qualified specialist after a comprehensive examination of the body. Remember that self-medication can be dangerous for your health, so a doctor's consultation is mandatory before starting therapy.

What is ASSURANS prescribed for?

The main medical indication for the prescription of this pharmaceutical preparation is pulmonary arterial hypertension of primary origin or caused by systemic connective tissue diseases. The use of the drug allows to significantly reduce pulmonary vascular resistance, which leads to improved systemic oxygen exchange. Patients taking this medication report a reduction in the severity of shortness of breath both during physical activity and at rest. Thanks to the therapy, the functional state of the cardiovascular system improves and the risk of developing heart failure decreases.

In addition, the drug is prescribed for increasing tolerance to physical activity in adult patients who have functional classes II and III of pathology according to the WHO classification. Regular intake helps people return to their usual rhythm of life and perform daily household chores without pronounced fatigue. The agent effectively prevents pathological narrowing of the pulmonary vascular bed and slows down structural changes in the arterial walls. The complex effect on vascular tone makes it an important component of basic medical support.

In some clinical cases, the medication may be used for secondary prevention of complications associated with chronic tissue hypoxia. The doctor considers the appropriateness of using the drug based on echocardiography indicators, catheterization of the right heart, and the general health status of the patient. It is important to take into account that the individual response of the body to pharmacotherapy may differ depending on concomitant diagnoses and age. The final decision on the appropriateness of the course is made by a cardiologist after assessing all risks.

Composition and active components of ASSURANS

The main active substance of this medicinal product is sildenafil in the form of citrate, which acts as a potent and selective inhibitor of a specific enzyme — phosphodiesterase type 5 (PDE-5). The mechanism of action of this compound is to increase the concentration of cyclic guanosine monophosphate (cGMP) in vascular smooth muscle cells. This causes a pronounced relaxation of the vascular wall and subsequent dilation of the arteries of the pulmonary circulation. Enzymatic blockade occurs locally, which minimizes the negative impact on systemic blood pressure, provided the recommended dosage is observed.

The tablet also contains specially selected excipients that ensure shape stability, proper dissolution, and optimal absorption of the active component. Among them are microcrystalline cellulose, calcium hydrogen phosphate, croscarmellose sodium, and magnesium stearate. The film coating protects the active substance from the aggressive effects of gastric juice and facilitates the swallowing process. All components meet strict pharmacopoeial requirements for purity and safety for the patient's body.

Dosage of ASSURANS

The standard recommended dosage of the medication for adult patients is usually 20 mg three times a day with an interval of approximately 6–8 hours between doses. Adherence to a clear time schedule allows to maintain a constant therapeutic concentration of the active substance in blood plasma throughout the day. Dose adjustment upwards or downwards is carried out exclusively by the treating doctor based on the assessment of the drug's efficacy and tolerability. It is not recommended to independently change the single or daily dose, as this may lead to a decrease in the therapeutic effect or the appearance of undesirable reactions.

For elderly patients, as well as individuals with mild or moderate hepatic or renal impairment, special adjustment of the starting dose is usually not required. However, in severe renal or hepatic impairment, the pharmacokinetics of substance elimination change, which requires careful medical monitoring and a possible reduction in dosing frequency. The duration of the treatment course is determined individually and is most often continuous, as the disease is chronic. Any changes in the dosage regimen must be agreed with a medical specialist.

How to take ASSURANS correctly?

The tablets are intended for oral use; they should be swallowed whole, without chewing or crushing, with a sufficient amount of clean drinking water. Food intake usually does not significantly affect the overall absorption of the active component, but consuming excessively fatty food may slightly delay the onset of pharmacological action. To ensure maximum efficacy, it is recommended to take the medication at the same time every day. This helps to form a habit and ensures stable control over vascular tone indicators.

If you accidentally miss a regular tablet dose, it should be taken as soon as you remember. However, if it is already time for the next scheduled dose, skip the missed one and return to your regular schedule. It is strictly forbidden to take a double dose of the drug to compensate for a missed one, as this creates a risk of overdose and a sharp drop in blood pressure. Remember that strict adherence to the instructions is the key to safe and effective treatment.

Side effects of ASSURANS

The most common side effects that may occur during the use of this medication are headache, hyperemia (flushing of the face), nasal congestion, and dyspeptic disorders. These symptoms are usually mild to moderate in severity and often decrease as the body adapts to the course of therapy. Patients also sometimes report dizziness, muscle or back pain, which is associated with the vasodilating effect of the active substance. Usually, such reactions do not require complete discontinuation of the drug.

Rare but more serious side effects include sudden hearing loss, visual disturbances (including changes in color perception or increased sensitivity to light), and pronounced arterial hypotension. If you experience a sharp deterioration in well-being, severe dizziness, or visual disturbances during therapy, you should immediately stop taking the drug and seek medical help. Remember that the individual response of the body can be unpredictable, so the assessment of the patient's condition by a doctor is mandatory at all stages of treatment.

Contraindications of ASSURANS

An absolute contraindication to the use of this pharmaceutical preparation is hypersensitivity to sildenafil or any of the excipients. Co-administration with nitric oxide donors, nitrates, or nitrites in any form is strictly prohibited, as this can cause a life-threatening drop in blood pressure. The drug is also contraindicated in patients with severe hepatic impairment, recent stroke or myocardial infarction, and individuals with pronounced arterial hypotension.

Special patient groups require extreme caution when designing a treatment regimen. The use of the drug during pregnancy and lactation is possible only in cases where the expected benefit to the mother significantly outweighs the potential risk to the fetus or child. The safety and efficacy of the drug in pediatric practice (for children and adolescents) have not been established, so it is not prescribed to this category of patients. Before starting the course, be sure to inform your doctor about all your concomitant diseases.

Interaction of ASSURANS with other drugs and alcohol

Concomitant use of the medication with potent CYP3A4 inhibitors (such as ketoconazole, itraconazole, or erythromycin) leads to a significant increase in sildenafil concentration in the blood, which requires dose adjustment. Co-administration with alpha-blockers used to treat high blood pressure or prostate adenoma may cause symptomatic hypotension. It is extremely important to provide your treating doctor with a complete list of all medications, dietary supplements, and vitamins you are currently taking to avoid dangerous drug combinations.

The consumption of alcoholic beverages during therapy with this drug is strongly discouraged. Ethanol enhances the vasodilating effect of sildenafil, which can lead to a sharp drop in blood pressure, severe dizziness, and even fainting. In addition, the ability to drive vehicles or operate precision machinery may be impaired due to possible side effects such as dizziness or visual disturbances. Patients should assess their individual response to the medication before driving.

Where to buy ASSURANS in Ukraine

This medicinal product is a prescription medication, so it can be purchased in pharmacies in Ukraine only with a properly executed prescription from a doctor. The drug is available for order both in traditional pharmacy chains and through specialized online pharmacy services with a booking option. The pharmaceutical product must be stored in its original packaging in a dry, dark place out of the reach of children at a temperature not exceeding 25 °C. Compliance with storage conditions guarantees the preservation of therapeutic properties throughout the shelf life.