Avanafil 100 mg: The Standard Dose for Ultra-Fast Action
Avanafil 100 mg (e.g., in medications Stendra 100 mg or generics Avana 100) is a modern medication for the treatment of erectile dysfunction (ED), belonging to the PDE5 inhibitor class. This is the standard recommended daily dose of the new-generation PDE5 inhibitor. It is intended for most men with ED and offers a unique combination of ultra-fast onset and high selectivity.
What is Avanafil 100 mg
Avanafil 100 mg is an oral medication containing 100 mg of Avanafil.
Indication and 100 mg Dosage
The 100 mg dose is the recommended starting and therapeutic dose for most men.
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For Starting: Doctors often prescribe 100 mg as the first dose to assess efficacy.
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Adjustment: If the effect is excessive or there are side effects, the dose is reduced to 50 mg. If the effect is insufficient (and the drug is well-tolerated), the dose can be increased to the maximum daily dose of 200 mg.
Key Advantages of Avanafil
Avanafil has two unique pharmacokinetic profiles:
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Ultra-Fast Start: This is the fastest PDE5 inhibitor. Due to rapid absorption, the effect can begin in as little as 15-20 minutes after intake (compared to 30-60 minutes for other drugs).
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High Selectivity: Avanafil acts very precisely on PDE5, and significantly less on other PDE types (PDE6 found in the retina or PDE11 in muscles). This ensures a lower risk of specific side effects characteristic of Sildenafil and Tadalafil.
Detailed Mechanism of Action of Avanafil
The mechanism of action of Avanafil is identical to other PDE5 inhibitors.
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Trigger: Sexual arousal causes the release of nitric oxide (NO).
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Erectile Cycle: NO stimulates the formation of cyclic GMP (cGMP), which relaxes the smooth muscles of the penile blood vessels, ensuring a powerful blood flow.
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PDE5 Blockade: Avanafil (at 100 mg) potently blocks the enzyme that degrades cGMP. Blocking this enzyme allows cGMP to persist longer, ensuring a stable, firm erection in response to stimulation.
Key takeaway: Avanafil 100 mg provides a rapid "window" of readiness (about 5-6 hours), but sexual arousal is always required to achieve an erection.
Instructions for Using Avanafil (100 mg)
Strict adherence to the instructions is necessary for safety and maximum efficacy.
Dosage and Timing of Intake
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Dosage: 100 mg (one tablet) – is the standard single dose.
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Frequency of Intake: Avanafil should be taken no more than once per day.
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Method: Swallow the tablet whole with water.
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Timing: Take 15–30 minutes before planned sexual activity.
Influence of Food and Alcohol
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Food: Unlike Sildenafil, taking Avanafil with a moderately high-fat meal does not significantly affect the onset of action.
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Alcohol: It is not recommended to combine Avanafil with excessive amounts of alcohol (more than 3 servings), as this can increase the risk of dropping blood pressure and dizziness.
Critical Contraindications
The list of contraindications related to the vasodilating effect is strict.
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Interaction with Nitrates: Absolutely forbidden! Taking Avanafil with any form of organic nitrates (Nitroglycerin) or nitric oxide donors ("poppers") causes a life-threatening drop in blood pressure.
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Severe Cardiovascular Diseases: Recent heart attack or stroke (within 6 months), severe heart failure, unstable angina.
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Blood Pressure: Persistent hypotension (pressure < 90/50 mmHg) or uncontrolled hypertension.
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Liver and Kindneys: Severe hepatic or renal failure.
Side Effects of Avanafil (100 mg)
Thanks to its high selectivity, Avanafil at 100 mg has one of the best safety profiles.
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Common: Headache, facial flushing, nasal congestion.
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Specific: Avanafil very rarely causes visual disturbances ("blue haze") or the back and muscle pain sometimes seen with Sildenafil or Tadalafil.
Immediate medical attention is required for: An erection that lasts longer than 4 hours (priapism), or sudden loss of vision/hearing.
Professional Advice on Using
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For Spontaneity: Avanafil 100 mg is the ideal choice for men who value spontaneity and do not want to wait an hour for the drug to take effect.
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Hydration: To minimize headaches, drinking enough water on the day of intake is recommended.
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Combinations: Avanafil is often combined with Dapoxetine (e.g., in Super Avana or Top Avana) for the simultaneous treatment of ED and premature ejaculation.
Avanafil 100 mg: Extended Q&A Section
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How long does Avanafil 100 mg last? The erection effect lasts about 5-6 hours.
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What is the difference between Avanafil (100 mg) and Sildenafil (100 mg)? Avanafil acts much faster (15-20 min vs 45-60 min) and has a lower risk of side effects related to vision and muscles.
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What should I do if 100 mg did not work? Ensure you took the drug and that there was sufficient sexual stimulation. If the effect is insufficient, consult your doctor about switching to 200 mg.
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Does Avanafil prolong sexual intercourse? No. Avanafil is intended only for ED treatment and does not affect the time to ejaculation.
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