Buy Dapoxetine 60 mg in Ukraine

Dapoxetine 60 mg: Review of the Maximum Dose for PE Treatment

Dapoxetine 60 mg (e.g., in generics like Poxet 60, Vriligy 60) is a medication containing the maximum recommended daily dose of Dapoxetine Hydrochloride. It is the only active ingredient specifically designed and clinically approved for the treatment of premature ejaculation (PE) in men aged 18 to 64.

It is important to understand that Dapoxetine does not treat erectile dysfunction (ED) and does not affect erection hardness. Its sole purpose is ejaculation control.

What is Dapoxetine and its indication?

Dapoxetine is a medication for "on-demand" use. Unlike traditional antidepressants, it belongs to the Selective Serotonin Reuptake Inhibitor (SSRI) class, but it has an ultra-short half-life (about 1.5–2 hours).

1. Indication and the 60 mg Dosage

The drug is indicated exclusively for the treatment of PE.

• Starting Dose (30 mg): The recommended initial dose for most men.

• Maximum Dose (60 mg): The Dapoxetine 60 mg dosage is used if 30 mg was insufficient for adequate control, provided the drug was well-tolerated.

Detailed Mechanism of Action of Dapoxetine

The mechanism of action of Dapoxetine is centered on the neurochemical processes in the central nervous system that regulate the ejaculation reflex.

1. Serotonin: Ejaculation is controlled by a complex chain of reflexes where serotonin (5-HT) plays a key inhibitory role. Low serotonin activity is associated with rapid ejaculation.

2. Action of Dapoxetine: Dapoxetine blocks the transporter proteins that carry out the reuptake of serotonin in neurons. This leads to a temporary and rapid increase in serotonin concentration in the synaptic cleft.

3. Result: The enhanced serotonergic transmission exerts an inhibitory effect on the brain and spinal cord centers that control ejaculation. This slows down nerve impulses and allows the man to significantly prolong sexual intercourse (by 3-4 times).

Key takeaway: The ultra-short action of Dapoxetine allows it to be taken "on-demand," without the drug accumulating in the body, which is typical of conventional SSRIs.

Instructions for Using Dapoxetine (60 mg)

Strict adherence to the rules for taking Dapoxetine 60 mg is critical to minimizing side effects, especially the risk of fainting (syncope).

1. Dosage and timing of intake

• Dosage: 60 mg – is the maximum daily dose. It is strictly prohibited to take more than 60 mg within 24 hours.

• Method: Swallow the tablet whole with a full glass (at least 250 ml) of water. Do not chew.

• Timing: Take 1–3 hours before planned sexual activity.

2. Influence of Alcohol

• Alcohol: ABSOLUTE PROHIBITION. Combining Dapoxetine with alcohol manifold increases the risk of neurocognitive side effects (dizziness, drowsiness, sluggishness) and can lead to fainting (syncope).

Critical Contraindications

The list of contraindications related to the drug's neurochemical action is very strict.

• Cardiovascular Disorders: Cardiac rhythm disturbances (blocks, bradycardia), severe heart failure, IHD.

• Hepatic Impairment: Severe and moderate severity.

• Psychiatric Disorders: History of mania, severe depression, uncontrolled bipolar disorder.

• Drug Interactions: Absolutely forbidden to take with:

  • MAO Inhibitors (MAOIs): Risk of serotonin syndrome.

  • Potent CYP3A4 Inhibitors: (Ketoconazole, Erythromycin, Grapefruit juice).

  • Other SSRIs: (Antidepressants).

Side Effects (Increased Risk at 60 mg)

At the 60 mg dose, side effects are more frequent and can be more pronounced than at 30 mg.

• Very Common: Nausea (the most common side effect), dizziness, headache.

• Common: Drowsiness, insomnia, anxiety, diarrhea, dry mouth.

• High Risk: Fainting (syncope) due to orthostatic hypotension.

Professional Advice on Using

1. Start with 30 mg: Never start treatment with 60 mg. The 60 mg dose is used only if 30 mg was ineffective but well-tolerated.

2. Take with water, while sitting: To minimize the risk of fainting, always take Dapoxetine while standing or sitting, washing it down with a full glass of water, and avoid standing up abruptly.

3. Combination Therapy: If you have both PE and ED, Dapoxetine 60 mg can be combined with PDE5 inhibitors (e.g., Sildenafil 100 mg or Tadalafil 20 mg), but this significantly increases the risk of side effects.

Dapoxetine 60 mg: Extended Q&A Section

• How much stronger is Dapoxetine 60 mg than 30 mg? The 60 mg dose provides a more pronounced and stable control over ejaculation compared to 30 mg, but it also significantly increases the risk of nausea and dizziness.

• How long does Dapoxetine 60 mg last? The ejaculation control effect lasts for 4-6 hours.

• How does Dapoxetine differ from delay sprays (Lidocaine)? Dapoxetine (pills) works "from the inside" via the brain, maintaining full sensitivity. Sprays (Lidocaine) work "from the outside," causing numbness and mechanically reducing sensitivity.