MALEGRA FXT

MALEGRA FXT is a specialized combination medication designed for men who face two concurrent sexual issues: erectile dysfunction (ED) and premature ejaculation (PE). This generic combines Sildenafil (100 mg) for erection improvement and Fluoxetine (40 mg) for prolongation of intercourse.

What is MALEGRA FXT?

MALEGRA FXT is a "2-in-1" medication containing the full standard dose of a PDE5 inhibitor and an effective dose of a prolonging agent.

1. Sildenafil Citrate (100 mg): The maximum standard dose for achieving and maintaining a firm erection.

2. Fluoxetine (40 mg): An active component belonging to the SSRI class (Selective Serotonin Reuptake Inhibitors). Fluoxetine is used to treat depression, but in the context of sexual health, it is effective for significantly prolonging intercourse.

1. Difference from "rapid" combination agents

Unlike medications with Dapoxetine, Fluoxetine in MALEGRA FXT has a long half-life (up to several days). This means that Fluoxetine accumulates in the body. Consequently, this drug is not intended for "on-demand" use but requires daily course intake to achieve the prolongation effect.

Dual mechanism of action of MALEGRA FXT

The medication acts simultaneously on the vascular system and neurochemical processes in the brain.

• Erection Improvement (Sildenafil 100 mg): Sildenafil blocks the PDE5 enzyme, leading to the relaxation of blood vessel smooth muscles and a powerful blood flow to the penis in response to sexual arousal.

• Ejaculation Control (Fluoxetine 40 mg): Fluoxetine increases the concentration of serotonin in the synaptic cleft. This exerts an inhibitory effect on the brain and spinal cord centers that control ejaculation. The 40 mg dose provides a more pronounced and sustained prolongation.

Key takeaway: Due to the presence of Fluoxetine, MALEGRA FXT is used to achieve sustained prolongation with regular intake (course therapy), distinguishing it from "rapid" combinations with Dapoxetine.

Instructions for using MALEGRA FXT: SPECIAL WARNING

Due to the long-acting nature of Fluoxetine, the administration of MALEGRA FXT is fundamentally different from typical "on-demand" drugs and must be done only under medical supervision.

1. Dosing regimen

• Dosage: 100 mg Sildenafil + 40 mg Fluoxetine is the maximum dose. It is strictly prohibited to take more than one tablet within 24 hours.

• Method: Swallow the tablet whole with water.

• Initiation of Therapy: Never start treatment with a whole MALEGRA FXT tablet. You should start with lower doses of Sildenafil (50 mg) and Fluoxetine (20 mg). The MALEGRA FXT tablet can be split for dose titration.

• Regularity: To achieve the prolongation effect, Fluoxetine requires daily course intake for several weeks to accumulate in the body.

2. Influence of alcohol

• Absolute prohibition. The combination of Fluoxetine and alcohol manifold increases the risk of sedative effects, impaired coordination, drowsiness, and may also lead to toxic liver damage.

Critical contraindications for MALEGRA FXT

The combination of two potent drugs requires the strictest adherence to contraindications.

• Interaction with Nitrates: Absolutely forbidden! Combining Sildenafil with any form of organic nitrates (Nitroglycerin) or nitric oxide donors ("poppers") causes a life-threatening drop in blood pressure.

• Serotonin Syndrome: Strictly forbidden to take with MAO Inhibitors (MAOIs), as well as with other SSRIs, SNRIs. Due to Fluoxetine, a "washout period" of up to 5 weeks from MAOIs is necessary.

• Cardiovascular Diseases: Recent heart attack or stroke, severe heart failure.

• Liver and Kidneys: Severe hepatic impairment (especially critical due to Fluoxetine).

• Blood Pressure: Uncontrolled hypertension or hypotension.

Side effects of MALEGRA FXT

Side effects are due to the cumulative effect of both components and are often more pronounced than with monotherapy.

• Common (from Sildenafil): Headache, facial flushing, visual disturbances ("blue haze").

• Common (from Fluoxetine): Nausea (pronounced, especially at the start of intake), insomnia, anxiety, dry mouth, sexual dysfunction (reduced libido, anorgasmia), which is paradoxical when treating PE.

Special Warning: Fluoxetine has a long-lasting effect that may persist after discontinuation.

Professional advice on using MALEGRA FXT

1. Necessity of Medical Control: MALEGRA FXT should only be used as part of PE course therapy prescribed by a urologist or sexologist and under strict monitoring.

2. Pill Splitting: The tablet can be split, allowing for the titration of Sildenafil (e.g., 50 mg) and Fluoxetine (20 mg) doses separately if needed.

3. Alternative: If you only require an "on-demand" effect (irregular sex), you should choose combinations with Dapoxetine.

MALEGRA FXT: Extended Q&A section

• What is the main difference between MALEGRA FXT and MALEGRA DXT (with Dapoxetine)?MALEGRA FXT uses Fluoxetine (long-acting), which requires daily intake for accumulation and PE control. MALEGRA DXT uses Dapoxetine (short-acting), which is taken "on demand."

• How long does the effect last? Sildenafil acts for 4–6 hours. The prolongation effect from Fluoxetine is continuous throughout the course of intake (as long as the drug is in the blood).

• Can MALEGRA FXT be taken as needed (only before sex)? No. Taking it only before sex will not provide the prolongation effect, as Fluoxetine will not accumulate. This drug is designed for daily, course-based application.

• Can Fluoxetine cause dependence? Fluoxetine, like any other SSRI, does not cause physical dependence, but it must not be abruptly discontinued. Discontinuation must be gradual, under a doctor's supervision.