POXET 90

Premature ejaculation (PE) is one of the most common male sexual dysfunctions, significantly impacting the quality of life. POXET 90 is a medication containing 90 mg of Dapoxetine, which is the maximum dose of this active substance. It is intended for the treatment of severe, lifelong, or acquired premature ejaculation.

What is POXET 90?

POXET 90 is a generic medication containing 90 mg of Dapoxetine Hydrochloride. Dapoxetine is the first and only drug specifically designed and approved for the treatment of PE.

1. Indication and dosage warning

Dapoxetine belongs to the Selective Serotonin Reuptake Inhibitor (SSRI) class but is distinguished by an ultra-short half-life (about 1.5–2 hours).

• Goal: Dapoxetine is clinically proven to significantly increase the Intravaginal Ejaculatory Latency Time (IELT), thereby giving the man control over the process.

• 90 mg Dosage: The standard starting dose of Dapoxetine is 30 mg, and the maximum approved daily dose is 60 mg. POXET 90 contains a dose that exceeds the standard maximum. This dose is intended exclusively for men with a severe form of PE who have not achieved an adequate response from the 60 mg dose and are under strict medical supervision.

Detailed mechanism of action of POXET 90

The mechanism of action of POXET 90 is linked to the neurochemistry of the brain.

1. Serotonin and PE: Serotonin is a key neurotransmitter influencing the ejaculatory reflex. Low serotonin levels or its rapid uptake in synapses are associated with rapid ejaculation.

2. Action of Dapoxetine: Dapoxetine blocks the transporter proteins that carry out the reuptake of serotonin (5-HT) in neurons. This leads to a temporary increase in serotonin concentration in the synaptic cleft.

3. Result: The elevated serotonin level acts on postsynaptic receptors, exerting an inhibitory effect on the brain and spinal cord centers that control ejaculation. This slows down the process and significantly prolongs sexual intercourse.

Key takeaway: Dapoxetine works quickly and is rapidly cleared from the body, allowing POXET 90 to be taken "on-demand" rather than as a course, like traditional antidepressants.

Instructions for using POXET 90: Specific precautions

Taking a dose as high as 90 mg requires maximum caution.

1. Dosage and timing of intake

• Dosage: 90 mg (one tablet) is a dose that exceeds the standard maximum. It is strictly prohibited to take more than 90 mg within 24 hours.

• Initial Dose: Never start with POXET 90! Start with 30 mg (1/3 of a tablet) or 60 mg (2/3 of a tablet, if 30 mg was ineffective). The 90 mg dose is only used upon a doctor's recommendation.

• Method: The tablet should be swallowed whole with a full glass of water.

• Timing: Take 1–3 hours before planned sexual activity.

2. Influence of food and alcohol

• Food: POXET 90 can be taken regardless of food intake.

• Alcohol: Absolute prohibition. Alcohol enhances the risk of neurocognitive side effects of Dapoxetine (dizziness, drowsiness, sluggishness) and can lead to fainting (syncope) and a sedative effect.

Critical contraindications for POXET 90

The list of contraindications related to the neurochemical action of the drug is very strict.

• Cardiovascular Disorders: Cardiac rhythm disturbances (blocks, severe heart failure), ischemic heart disease.

• Hepatic Impairment: Severe and moderate severity.

• Psychiatric Disorders: History of mania, severe depression, uncontrolled bipolar disorder.

• Drug Interactions: Absolutely forbidden to take with:

  • MAO Inhibitors (MAOIs): Risk of serotonin syndrome.

  • Potent CYP3A4 Inhibitors: (Ketoconazole, Erythromycin, Grapefruit juice). Increases Dapoxetine concentration and the risk of fainting.

  • Other SSRIs: (Antidepressants).

Side effects of POXET 90 (Increased risk)

At the 90 mg dose, the risk and intensity of side effects characteristic of SSRIs increase.

• Very Common: Nausea (the most common side effect), dizziness, headache, diarrhea.

• Common: Drowsiness, insomnia, anxiety, dry mouth, increased fatigue.

Special Warning: Due to the high dosage, there is an increased risk of fainting (syncope), which is often preceded by nausea, dizziness, and sweating.

Professional advice on using POXET 90

1. Take while sitting or standing: To minimize the risk of fainting (orthostatic hypotension), always take POXET 90while sitting or standing, washing it down with a full glass of water. Avoid standing up abruptly after intake.

2. Not for daily use: Dapoxetine is an "on-demand" drug. It should not be taken daily or as a course.

3. Pill Splitting: POXET 90 should be split into 3 parts of 30 mg for safe and economical use. Always start with 30 mg.

POXET 90: Extended Q&A section

• How much does POXET 90 prolong intercourse? Clinical studies of Dapoxetine show an increase in Ejaculatory Latency Time (IELT) by 3–4 times or more, depending on the dose. For 90 mg, the prolongation effect will be maximal.

• How soon does POXET 90 start working? Due to its fast metabolism, the effect begins to manifest after 60 minutes, with the peak effect occurring 1–2 hours after intake.

• Can POXET 90 be taken with erection drugs (Sildenafil, Tadalafil)? Yes. Dapoxetine is often combined with PDE5 inhibitors for a dual effect (firm erection + control). However, this combination requires even stricter exclusion of contraindications, as the vasodilating effect of PDE5 inhibitors sums with the potential risk of hypotension from Dapoxetine.

• Can I take POXET 90 if I don't have PE but want to prolong sex? Dapoxetine is indicated only for a confirmed diagnosis of PE. Taking the drug without indication is not recommended due to the potentially high risk of neurochemical side effects.