POXET 60

Premature ejaculation (PE) is a common issue, and POXET 60 offers the strongest, clinically approved solution for its treatment. The medication contains 60 mg of Dapoxetine Hydrochloride – the maximum dose officially recommended to achieve optimal control and significantly prolong intercourse time.

What is POXET 60?

POXET 60 is a generic medication whose active substance is Dapoxetine. Dapoxetine is a unique drug belonging to the Selective Serotonin Reuptake Inhibitor (SSRI) class, specifically developed for "on-demand" use (right before sexual intercourse), thanks to its ultra-short half-life.

1. Indication and purpose of the dosage

The drug is intended for the treatment of PE in men aged 18–64. The 60 mg dose is used when the initial 30 mg dose provides insufficient control or fails to produce the desired effect.

• Therapy Goal: Dapoxetine is proven to increase the Intravaginal Ejaculatory Latency Time (IELT) by 3–4 times, significantly enhancing sexual satisfaction.

• 60 mg: This is the maximum dose where the efficacy-to-safety ratio is considered acceptable.

Detailed mechanism of action of POXET 60

The mechanism of action of POXET 60 is centered on the neurochemical processes in the central nervous system that regulate the ejaculation reflex.

1. Serotonin: Ejaculation is controlled by a complex chain of reflexes where serotonin (5-HT) plays a key inhibitory role. Lower serotonin activity is associated with rapid ejaculation.

2. Action of Dapoxetine: Dapoxetine blocks the reuptake of serotonin by neurons. This leads to a temporary and rapid increase in serotonin concentration in the synaptic cleft.

3. Result: The enhanced stimulation of postsynaptic serotonin receptors exerts an inhibitory effect on the brain and spinal cord centers that control ejaculation. This slows down nerve impulses and allows the man to significantly prolong the time until orgasm.

Key takeaway: The ultra-short action of Dapoxetine allows POXET 60 to be taken only when needed, without causing the typical side effects associated with daily, long-term SSRI intake.

Instructions for using POXET 60

Strict adherence to the rules for taking POXET 60 is critical to minimizing side effects, especially the risk of fainting (syncope).

1. Dosage and timing of intake

• Dosage: 60 mg (one tablet) is the maximum recommended daily dose. It is strictly prohibited to exceed 60 mg within 24 hours.

• Initial Dose: POXET 60 is not the starting dose. You should start with 30 mg. The transition to 60 mg occurs only if the 30 mg dose did not provide sufficient effect and was well-tolerated.

• Method: Swallow the tablet whole with a full glass (at least 250 ml) of water. Do not chew.

• Timing: Take 1–3 hours before planned sexual activity.

2. Influence of alcohol

• Alcohol: Absolute prohibition. Alcohol enhances the risk of neurocognitive side effects of Dapoxetine (dizziness, drowsiness, sluggishness), which can lead to fainting (syncope) and sedation.

Critical contraindications for POXET 60

The list of contraindications related to the drug's neurochemical action is very strict.

• Cardiovascular Disorders: Presence of cardiac rhythm disturbances, severe heart failure, or taking drugs that prolong the QT interval.

• Hepatic Impairment: Severe and moderate severity.

• Psychiatric Disorders: History of mania, severe depression, uncontrolled bipolar disorder.

• Drug Interactions: Absolutely forbidden to take with:

  • MAO Inhibitors (MAOIs): Risk of serotonin syndrome.

  • Potent CYP3A4 Inhibitors: (Ketoconazole, Erythromycin, Grapefruit juice). Sharply increases Dapoxetine concentration and the risk of fainting.

  • Other SSRIs: (Antidepressants).

Side effects of POXET 60 (Increased risk)

At the 60 mg dose, the risk and intensity of side effects typical of SSRIs increase compared to 30 mg.

• Very Common: Nausea (the most frequent side effect), dizziness, headache.

• Common: Drowsiness, insomnia, anxiety, diarrhea, dry mouth.

Special Warning: Due to the elevated dosage, there is an increased risk of fainting (syncope), which typically occurs within the first three hours after intake and is often linked to insufficient water consumption.

Professional advice on using POXET 60

1. Take with water, while sitting: To minimize the risk of fainting (orthostatic hypotension), always take POXET 60with a full glass of water and avoid standing up abruptly immediately after intake.

2. Pill Splitting: The 60 mg tablet should be split into two 30 mg portions for starting therapy or to reduce risks if 60 mg causes side effects. This allows for safe dose titration.

3. Combination Therapy: POXET 60 can be safely combined with PDE5 inhibitors (Sildenafil, Tadalafil) for a dual effect (PE control + firm erection), provided all contraindications are excluded.

POXET 60: Extended Q&A section

• How much more effective is POXET 60 than 30 mg? Clinical data show that 60 mg provides a greater degree of control and significantly prolongs intercourse more than 30 mg, but with an increased risk of side effects. If 30 mg yields a sufficient result, 60 mg should not be taken.

• How soon does POXET 60 start working? Due to rapid absorption and clearance, the effect begins after 60 minutes, with the peak effect occurring 1–2 hours after intake.

• How long does the prolongation effect last? The ejaculation control effect lasts for 3–4 hours after the peak concentration, which is optimal for "on-demand" use.

• What is syncope (fainting) related to Dapoxetine? It is a sudden loss of consciousness caused by orthostatic hypotension (a sharp drop in blood pressure upon changing body position). Taking POXET 60 with water and avoiding sudden movements are the main prophylactic measures.