LOVEVITRA 40

In the treatment of erectile dysfunction (ED), there are challenging cases where the standard maximum dose of Vardenafil (20 mg) is not sufficient. LOVEVITRA 40 is a medication containing a high concentration of Vardenafil (40 mg). It is intended for men with pronounced, resistant ED who require a more potent effect.

What is LOVEVITRA 40?

LOVEVITRA 40 is a generic manufactured in India, containing 40 mg of Vardenafil.

1. Indication and warning about the dosage

It must be clearly understood: the standard maximum daily dose of Vardenafil approved by regulatory bodies is 20 mg. The 40 mg dosage offered by LOVEVITRA 40 doubles this standard.

This medication should never be used as a first or standard dose. It is intended for:

• Patients for whom 20 mg of Vardenafil did not yield the expected therapeutic response (resistance).

• Men with severe coexisting conditions (e.g., severe diabetes) requiring an increased concentration to compensate for vascular impairments.

• Patients with high body mass.

Detailed mechanism of action of Vardenafil

Vardenafil, the active component of LOVEVITRA 40, is a highly selective inhibitor of the PDE5 enzyme. Its high selectivity minimizes the impact on other enzymes, which is its key advantage over Sildenafil.

1. Erectile Cycle: Sexual stimulation causes the release of nitric oxide (NO), which activates the production of cyclic GMP (cGMP). cGMP causes smooth muscle relaxation and artery widening, leading to blood inflow and an erection.

2. PDE5 Blockade: The PDE5 enzyme normally breaks down cGMP. Vardenafil blocks PDE5. The 40 mg dose in LOVEVITRA 40 ensures powerful inhibition, allowing cGMP to persist longer, enhancing and stabilizing the erection.

Important to remember: LOVEVITRA 40 does not cause spontaneous arousal; it only enhances the natural physiological response.

Instructions for using LOVEVITRA 40: Safety rules

Taking a dose as high as 40 mg requires extreme caution and monitoring.

1. Dosing recommendations

• Initial Use: It is strictly forbidden to start treatment with a whole 40 mg tablet. Always start with 1/4 of a tablet (10 mg) or 1/2 of a tablet (20 mg).

• Maximum Daily Dose: 40 mg is the absolute maximum. You must not take more than one LOVEVITRA 40 tablet within a 24-hour period.

• Practicality: The sensible use of LOVEVITRA 40 is to split it into two maximum standard doses of 20 mg.

• Method of Intake: Swallow the tablet whole with water, 30-60 minutes before sexual intercourse.

2. Interaction with food and alcohol

• Food: Vardenafil is less food-dependent than Sildenafil. Nevertheless, for the fastest and strongest effect, taking LOVEVITRA 40 on an empty stomach is recommended.

• Alcohol: Combining 40 mg of Vardenafil and alcohol is not recommended. A high dose of a vasodilator combined with alcohol can cause a severe drop in blood pressure, dizziness, and fainting.

Critical contraindications for LOVEVITRA 40

Due to the increased dosage, the risks of interaction are heightened.

• Interaction with Nitrates: Absolutely forbidden to take LOVEVITRA 40 with any form of nitrates or nitric oxide donors (e.g., Nitroglycerin). A whole tablet combined with nitrates causes a fatally dangerous drop in blood pressure.

• Cardiovascular Diseases: Recent heart attack or stroke (within 6 months), unstable angina, severe heart failure.

• Liver and Kidneys: Severe liver impairment (Child-Pugh Class C) or kidney failure requiring dialysis.

• Blood Pressure: Hypotension (persistent pressure < 90/50 mmHg) or uncontrolled hypertension.

Side effects of LOVEVITRA 40: Increased Risk

At the 40 mg Vardenafil dosage, the probability and intensity of side effects are significantly higher compared to 20 mg.

• Very Common: Severe headache, pronounced facial flushing, nasal congestion.

• Common: Dizziness, dyspepsia (upset stomach), back and muscle pain (myalgia).

• Increased Risk of Serious Effects: Priapism (painful erection lasting longer than 4 hours), sudden loss of vision or hearing, severe hypotension.

Professional advice on using LOVEVITRA 40

1. Splitting is safety and economy: LOVEVITRA 40 is ideal for splitting. By dividing it into two parts, you get two maximum standard doses of 20 mg. This gives maximum efficacy with lower risk.

2. Do not chase the dose: If 20 mg of Vardenafil provides a sufficient effect, switching to 40 mg will not increase the duration of the erection (it remains 4-6 hours) but will increase the risk of adverse reactions.

3. Ideal choice for diabetics: Vardenafil is known for its high efficacy in men with diabetes. LOVEVITRA 40 may be appropriate for this group, but only after gradual dose escalation under medical supervision.

LOVEVITRA 40: Extended Q&A section

• How long does LOVEVITRA 40 last? The duration of Vardenafil's action does not depend on the dose. The effect is maintained for 4-6 hours.

• Can I take LOVEVITRA 40 if 10 mg of Sildenafil was ineffective? Switching from one class of PDE5 inhibitors to another is often effective. However, starting LOVEVITRA 40 should be done with a 10 mg dose (1/4 tablet), not a whole tablet.

• How does Vardenafil differ from Sildenafil? Vardenafil (the active ingredient in LOVEVITRA 40) is considered more selective, which reduces the risk of vision-related side effects (changes in color perception).

• Is a doctor's consultation required before taking 40 mg? Yes, it is mandatory. The 40 mg dose exceeds the therapeutic maximum. It requires an assessment of cardiovascular risks and interactions with other medications that might interact with Vardenafil.