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"Female Sildenafil": Review and mechanism of action of the "Pink Pill"

"Female Sildenafil" (often known by the brand name Lovegra or Malegra-100 FEM) is a medication containing Sildenafil Citrate (usually 100 mg). It has been adapted to address issues of female sexual dysfunction, specifically, Female Sexual Arousal Disorder (FSAD).

It is important to understand that "Female Sildenafil" is not a drug for enhancing libido (desire). Its action, like male Viagra, is purely vascular in nature.

What is Female Sildenafil and its purpose?

"Female Sildenafil" is a PDE5 inhibitor intended for women who experience sexual desire but face physical difficulties during arousal.

1. Indication and target audience

The medication is intended for women who experience:

  • Insufficient Lubrication: Difficulty with natural vaginal moisture during stimulation.

  • Low Sensitivity: Reduced sensitivity of the clitoris and other erogenous zones.

  • Arousal-related Anorgasmia: Difficulty reaching orgasm due to an insufficient physical response.

2. The 100 mg Dosage

The 100 mg dose is the maximum standard daily dose of Sildenafil. However, for women, especially on the first intake, this dose is often excessive.

Doctor's Recommendation: You should start with 1/4 of a tablet (25 mg) or 1/2 of a tablet (50 mg) to assess individual response and minimize the risk of side effects.

Detailed mechanism of action of Sildenafil in women

The mechanism of action of "Female Sildenafil" is based on blocking the PDE5 enzyme.

  1. Trigger: The process begins with psychological sexual arousal (desire, thoughts, stimulation). The brain sends signals, releasing nitric oxide (NO) in the genital area.

  2. cGMP Cycle: NO activates an enzyme that produces cyclic GMP (cGMP). cGMP is the key substance that causes the smooth muscles of blood vessels to relax.

  3. PDE5 Blockade: Sildenafil blocks the PDE5 enzyme, which degrades cGMP. This allows cGMP to accumulate in high concentrations and last longer.

  4. Result in Women:

    • Enhanced Engorgement: A powerful rush of blood to the clitoris and labia minora occurs. The clitoris swells, similar to a male erection.

    • Increased Sensitivity: The engorged clitoris becomes hypersensitive to stimulation.

    • Improved Lubrication: Increased blood flow to the vaginal mucosa stimulates the Bartholin's glands, leading to abundant natural lubrication.

Key takeaway: "Female Sildenafil" does not create desire. It only enhances the physical response to pre-existing arousal.

Instructions for using "Female Sildenafil"

Strict adherence to the instructions is necessary for safety and efficacy.

1. Dosage and timing of intake

  • Starting Dose: 25-50 mg.

  • Maximum Daily Dose: 100 mg (one tablet). It is strictly prohibited to take more than 100 mg within 24 hours.

  • Method: Swallow the tablet whole with a full glass of water.

  • Timing: Take 45–60 minutes before planned sexual activity. The effect lasts 4–6 hours.

2. Influence of food and alcohol

  • Food: Taking "Female Sildenafil" with a heavy, fatty meal can significantly delay the onset of action (up to 90 minutes). For a faster effect, take it on an empty stomach.

  • Alcohol: It is not recommended to combine Sildenafil intake with excessive amounts of alcohol, as this can enhance the vasodilating effect and increase the risk of headaches and hypotension.

Critical contraindications

The list of contraindications related to the vasodilating effect is strict.

  • Interaction with Nitrates: Absolutely forbidden! Taking "Female Sildenafil" with any form of organic nitrates (Nitroglycerin) or nitric oxide donors ("poppers") causes a life-threatening drop in blood pressure.

  • Pregnancy and Lactation: The drug is not intended for use by pregnant or breastfeeding women.

  • Severe Cardiovascular Diseases: Recent heart attack or stroke (within 6 months), unstable angina, severe heart failure.

  • Blood Pressure: Persistent hypotension (pressure < 90/50 mmHg) or uncontrolled hypertension.

  • Liver and Kidneys: Severe hepatic or renal failure.

Side effects of "Female Sildenafil"

Side effects are identical to those in men:

  • Common: Headache (most common effect), facial flushing, nasal congestion, dyspepsia.

  • Less Common: Visual disturbances (temporary change in color perception, "blue haze"), dizziness.

Professional advice on using

  1. Dosing Flexibility: Start with 25 mg or 50 mg (1/4 or 1/2 tablet). If this dose is sufficient, there is no need to take 100 mg and increase the risks of side effects.

  2. Not for Libido Treatment: If the primary problem is a lack of sexual desire (HSDD), "Female Sildenafil" will not help. In this case, a doctor should be consulted to consider other options, such as Flibanserin.

  3. Hydration: To minimize headaches, drinking enough water on the day of intake is recommended.

"Female Sildenafil": Extended Q&A section

  • How does "Female Sildenafil" differ from "Female Cialis"? The main difference is duration. "Female Sildenafil" (Lovegra) lasts 4–6 hours, while "Female Cialis" (Tadadel FM, Tadalista) lasts up to 36 hours.

  • How long does the drug last? The effect lasts 4–6 hours.

  • Can I take "Female Sildenafil" if I don't have arousal problems? The drug is intended only for the treatment of FSAD. Intake without indication can lead to unnecessary side effects.

  • Will "Female Sildenafil" help me reach orgasm? Indirectly, yes. By increasing blood flow and sensitivity, the drug can make it easier to achieve orgasm with adequate stimulation, but it does not guarantee it.

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