TADALISTA 40

TADALISTA 40 is a medication containing 40 mg of Tadalafil, which is double the maximum standard dose ("the weekend pill"). This dosage is categorically not intended for a single intake. The primary purpose of TADALISTA 40 is to provide patients with an economical way to obtain two standard doses (20 mg) or four starting doses (10 mg) by splitting the tablet.

What is TADALISTA 40?

TADALISTA 40 is a generic containing 40 mg of Tadalafil. Tadalafil is a PDE5 inhibitor with a unique duration of action of up to 36 hours.

1. Indication and dosage warning

It must be strictly understood: the standard maximum daily dose of Tadalafil approved by regulatory bodies is 20 mg. The 40 mg dosage offered by TADALISTA 40 doubles this standard.

This medication should never be used for taking a whole tablet at once. It is intended for:

• Economy: Splitting the 40 mg tablet into 2 parts (20 mg each) or 4 parts (10 mg each) significantly reduces the cost of treatment.

• Severe ED: In very rare, resistant cases, a doctor might prescribe a higher dose, but 40 mg at once is a high load on the body.

Detailed mechanism of action of Tadalafil

The mechanism of action of TADALISTA 40 is based on Tadalafil being a potent and selective inhibitor of the PDE5 enzyme.

1. Trigger: Sexual arousal causes the release of nitric oxide (NO).

2. Erectile Cycle: NO stimulates the formation of cyclic GMP (cGMP), which relaxes the smooth muscles of the penile blood vessels, ensuring blood flow.

3. PDE5 Blockade: Tadalafil blocks the PDE5 enzyme that degrades cGMP. Blocking this enzyme allows cGMP to persist longer, ensuring a stable erection.

4. Duration: Tadalafil's half-life (17.5 hours) provides a "window" of efficacy for up to 36 hours.

Key takeaway: TADALISTA 40 provides a prolonged "window" of readiness, but sexual arousal is always required to achieve an erection.

Instructions for using TADALISTA 40: Safety rules

Taking a dose as high as 40 mg requires extreme caution and monitoring.

1. Dosing recommendations

• Initial Use: It is strictly forbidden to start treatment with a whole 40 mg tablet. Always start with 1/4 of a tablet (10 mg).

• Standard Maximum Dose: 1/2 of a tablet (20 mg).

• Maximum Daily Dose: Do not take more than 20 mg (1/2 of a tablet) within 24–36 hours.

• Method: Swallow the tablet whole with water.

• Timing: Take 30–60 minutes before planned sexual activity.

2. Interaction with food and alcohol

• Food: TADALISTA 40 can be taken regardless of food.

• Alcohol: Combining 40 mg of Tadalafil and alcohol is not recommended, as it can increase the risk of dropping blood pressure and dizziness.

Critical contraindications

Due to the increased dosage, the risks of interaction are heightened.

• Interaction with Nitrates: Absolutely forbidden! Taking TADALISTA 40 with any form of nitrates or nitric oxide donors (e.g., Nitroglycerin) causes a life-threatening drop in blood pressure.

• Severe Cardiovascular Diseases: Recent heart attack or stroke (within 6 months), unstable angina, severe heart failure.

• Blood Pressure: Persistent hypotension (pressure < 90/50 mmHg) or uncontrolled hypertension.

• Liver and Kidneys: Severe hepatic or renal failure.

Side effects of TADALISTA 40: Increased Risk

At a 40 mg dosage (if the whole tablet is taken), the probability and intensity of side effects increase significantly.

• Very Common: Severe headache, dyspepsia, pronounced back pain and muscle aches (myalgia), flushing.

• Increased Risk of Serious Effects: Priapism (painful erection lasting longer than 4 hours), sudden loss of vision or hearing, severe hypotension.

Professional advice on using

1. Splitting is the key to safety and economy: TADALISTA 40 is ideal for splitting. By dividing it into two parts, you get two maximum standard doses of 20 mg. This gives maximum efficacy with lower risk.

2. Do not chase the dose: If 20 mg of Tadalafil provides a sufficient effect, switching to 40 mg will not increase the duration of the erection (it remains up to 36 hours), but will sharply increase the risk of adverse reactions.

TADALISTA 40: Extended Q&A section

• How long does TADALISTA 40 last? The duration of Tadalafil's action does not depend on the dose. The effect is maintained for up to 36 hours.

• Can I take TADALISTA 40 if 20 mg did not work? The transition to a higher dose is only possible after consulting a doctor. Always start with 1/2 tablet (20 mg) to assess tolerability.

• How does Tadalafil differ from Sildenafil? Tadalafil (the active substance in TADALISTA 40) acts for up to 36 hours; Sildenafil acts for 4-6 hours.

• Is a doctor's consultation required before taking 40 mg? Yes, it is mandatory. The 40 mg dose is double the therapeutic maximum.