MALEGRA FXT Plus

MALEGRA FXT PLUS is a specialized combination medication intended for men facing two major sexual issues: erectile dysfunction (ED) and premature ejaculation (PE). This generic is unique because it combines two active substances, each providing a potent effect in its respective area: Sildenafil (100 mg) for erection and Fluoxetine (60 mg)for prolongation.

What is MALEGRA FXT PLUS?

MALEGRA FXT PLUS is a "2-in-1" medication containing the maximum standard dose of a PDE5 inhibitor and a high dose of a prolonging agent.

1. Sildenafil Citrate (100 mg): The maximum standard dose for guaranteed achievement of a firm erection (as in Viagra).

2. Fluoxetine (60 mg): An active component belonging to the SSRI class (Selective Serotonin Reuptake Inhibitors) used for treating depression, but in the context of sexual health, it is effective for significantly prolonging intercourse.

1. Difference from other combination agents

Unlike medications using Dapoxetine (a short-acting SSRI taken "on demand"), Fluoxetine in MALEGRA FXT PLUShas a long half-life. This means that Fluoxetine accumulates in the body. Consequently, this drug is not intended for single-use and carries entirely different risks and administration requirements.

Dual mechanism of action of MALEGRA FXT PLUS

The medication acts simultaneously on the vascular and neurochemical systems.

• Erection Improvement (Sildenafil 100 mg): Sildenafil blocks PDE5, leading to the relaxation of penile blood vessels and a powerful blood flow in response to sexual arousal.

• Ejaculation Control (Fluoxetine 60 mg): Fluoxetine increases the concentration of serotonin in the synaptic cleft. This exerts a powerful inhibitory effect on the brain and spinal cord centers that control ejaculation, leading to multi-fold prolongation of intercourse time.

Key takeaway: Due to the presence of Fluoxetine, MALEGRA FXT PLUS is used to achieve sustained prolongation with regular intake (course therapy), which differentiates it from "rapid" combinations with Dapoxetine.

Instructions for using MALEGRA FXT PLUS: SPECIAL WARNING

Due to the long-acting nature of Fluoxetine, the administration of MALEGRA FXT PLUS is fundamentally differentfrom typical "on-demand" drugs and must be done only under medical supervision.

1. Dosing regimen

• Dosage: 100 mg Sildenafil + 60 mg Fluoxetine is the maximum dose.

• Method: Swallow the tablet whole with water.

• Initiation of Therapy: Never start treatment with a whole MALEGRA FXT PLUS tablet. You should start with lower doses of Sildenafil (50 mg) and Fluoxetine (10–20 mg) to rule out individual intolerance. The MALEGRA FXT PLUS tablet can be split for dose titration.

• Regularity: To achieve the prolongation effect, Fluoxetine requires daily course intake for several weeks to accumulate in the body.

2. Influence of alcohol

• Absolute prohibition. The combination of Fluoxetine and alcohol manifold increases the risk of sedative effects, impaired coordination, drowsiness, and may also lead to toxic liver damage.

Critical contraindications for MALEGRA FXT PLUS

The combination of two potent drugs requires the strictest adherence to contraindications.

• Interaction with Nitrates: Absolutely forbidden! Combining Sildenafil with any form of organic nitrates (Nitroglycerin) or nitric oxide donors causes a life-threatening drop in blood pressure.

• Serotonin Syndrome: Strictly forbidden to take with MAO Inhibitors (MAOIs), as well as with other SSRIs, SNRIs, or triptans. Due to Fluoxetine's long half-life, a "washout period" of up to 5 weeks from MAOIs is necessary.

• Cardiovascular Diseases: Recent heart attack or stroke, severe heart failure.

• Liver and Kidneys: Severe hepatic impairment (especially critical due to Fluoxetine).

• Blood Pressure: Uncontrolled hypertension or hypotension.

Side effects of MALEGRA FXT PLUS

Side effects are due to the cumulative effect of both components and are often more pronounced than with monotherapy.

• Common (from Sildenafil): Headache, facial flushing, visual disturbances ("blue haze").

• Common (from Fluoxetine): Nausea (pronounced, especially at the start of intake), insomnia, anxiety, dry mouth, sexual dysfunction (reduced libido, anorgasmia), which is paradoxical when treating PE.

Special Warning: Fluoxetine has a long-lasting effect that may persist after discontinuation.

Professional advice on using MALEGRA FXT PLUS

1. Necessity of Medical Supervision: MALEGRA FXT PLUS should only be used as part of PE course therapy prescribed by a urologist or sexologist and under strict monitoring. Self-medication with this combination is very dangerous.

2. Pill Splitting: The tablet can be split, allowing for the titration of Sildenafil (e.g., 50 mg) and Fluoxetine (30 mg) doses separately if needed.

3. Alternative: If you only require an "on-demand" effect, you should choose combinations with Dapoxetine (e.g., Super P-Force), which is rapidly cleared from the body.

MALEGRA FXT PLUS: Extended Q&A section

• What is the main difference between MALEGRA FXT PLUS and MALEGRA DXT (with Dapoxetine)?MALEGRA FXT PLUS uses Fluoxetine (long-acting SSRI), which requires daily intake for accumulation and continuous PE control. MALEGRA DXT uses Dapoxetine (short-acting), which is taken "on demand" (1–3 hours before intercourse).

• How long does the effect last? Sildenafil acts for 4–6 hours. The prolongation effect from Fluoxetine is continuous throughout the course of intake (as long as the drug is in the blood).

• Can MALEGRA FXT PLUS be taken as needed (only before sex)? Taking it only before sex will not provide any prolongation effect, as Fluoxetine will not have time to accumulate to the required concentration. This drug is designed for daily, course-based application.

• Can Fluoxetine cause dependence? Fluoxetine, like any other SSRI, does not cause physical dependence, but it should not be abruptly discontinued. Discontinuation must be gradual, under a doctor's supervision, to avoid SSRI discontinuation syndrome.