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FLIBAN (Flibanserin): Review of the medication for reduced libido in women

FLIBAN is a medication whose active ingredient is Flibanserin (100 mg). It is the world's first drug approved by the FDA (U.S. Food and Drug Administration) specifically for the treatment of Hypoactive Sexual Desire Disorder (HSDD)in premenopausal women.

It is important to understand: FLIBAN is not a "female Viagra." It has a completely different mechanism of action, targeting not physical arousal, but the brain chemistry responsible for sexual desire (libido).

What is HSDD and who is FLIBAN indicated for?

HSDD (Hypoactive Sexual Desire Disorder) is a condition characterized by a persistent or recurrent absence of sexual thoughts, fantasies, and desire, which causes personal distress for the woman.

FLIBAN is indicated exclusively for treating this condition in women for whom:

• The low libido is not caused by medical conditions (e.g., hormonal imbalance), psychiatric disorders (depression), or relationship problems.

• The low libido causes stress and dissatisfaction.

Detailed mechanism of action of FLIBAN (Flibanserin)

FLIBAN is not a stimulant or an aphrodisiac. It is a neuromodulator that acts on the central nervous system.

The mechanism of action of Flibanserin involves restoring the balance of neurotransmitters (chemical messengers) in the brain that regulate sexual desire:

1. Decreases Serotonin (Inhibition): It acts as an agonist at the 5-HT1A receptor and an antagonist at the 5-HT2A receptor. This leads to a decrease in the level of serotonin, which often "suppresses" sexual desire.

2. Increases Dopamine and Norepinephrine (Excitation): Simultaneously, the drug increases the levels of dopamine and norepinephrine – neurotransmitters responsible for motivation, pleasure, and arousal.

Key takeaway: FLIBAN is NOT an "on-demand" pill. You cannot take it an hour before sex and get results. It is a course-based medication.

Instructions for use: Course-based intake

To achieve a therapeutic effect, Flibanserin requires accumulation in the body.

• Dosage: 100 mg (one tablet).

• Frequency of Intake: Strictly once daily, at bedtime.

• Why at bedtime? Taking the drug during the day can cause severe dizziness, drowsiness, and hypotension (drop in blood pressure). Taking it at night minimizes these risks.

• Course: The effect develops gradually. The first improvements may be seen after 3-4 weeks. The maximum effect is achieved after 6-8 weeks of daily intake.

Critical contraindications and risks

FLIBAN has very strict limitations due to the risk of serious side effects.

• ALCOHOL: ABSOLUTELY FORBIDDEN! Concomitant use of FLIBAN and alcohol (even in small amounts) can cause severe hypotension (dangerous drop in blood pressure) and syncope (fainting).

• Drug Interactions: Forbidden to take with:

  • Potent CYP3A4 Inhibitors: (Ketoconazole, Itraconazole, Erythromycin, Grapefruit juice). They sharply increase the concentration of Flibanserin, increasing the risk of fainting.

  • MAO Inhibitors (MAOIs): Risk of serotonin syndrome.

  • Other CNS depressants (sleeping pills, tranquilizers).

• Liver Disease: Contraindicated in any form of hepatic impairment.

Side effects of FLIBAN

The most common side effects (especially with daytime dosing):

• Dizziness.

• Drowsiness, fatigue.

• Nausea.

• Dry mouth.

• Fainting (syncope) – especially when combined with alcohol.

Professional advice on using

1. This is not Viagra: FLIBAN treats desire (libido). If you have desire but lack physical arousal (dryness, low sensitivity), you need Sildenafil-based drugs (Lovegra) or Tadalafil-based drugs (Tadadel FM).

2. Doctor consultation is necessary: Before taking, a consultation with a gynecologist and/or sexologist is required to rule out other causes of low libido (depression, hormonal imbalance, relationship issues).

3. Patience: The drug's effect develops slowly. Do not expect results in the first week.

FLIBAN: Extended Q&A section

• How long does FLIBAN last? It is a course-based drug. It works 24/7 while you are taking it by maintaining a neurochemical balance.

• Can I take FLIBAN if I drink a glass of wine? No. Even one glass of wine combined with Flibanserin can cause fainting.

• What if I miss a dose? If you miss your bedtime dose, just skip it. Do not take two tablets the next morning.

• Can men take FLIBAN? No. The drug is designed, tested, and approved exclusively for the treatment of HSDD in women.