Stendra 200 mg: The Maximum Dose of Avanafil for Ultra-Fast Action
Stendra 200 mg is the original, brand-name medication whose active ingredient is Avanafil (200 mg). This is the maximum recommended daily dose of the new-generation PDE5 inhibitor. It is intended for men with erectile dysfunction (ED) for whom the standard 100 mg dose did not provide a sufficient effect.
What is Stendra 200 mg?
Stendra 200 mg is an oral medication containing 200 mg of Avanafil.
Indication and 200 mg Dosage
The 200 mg dose is not a starting dose. It is intended exclusively for men who:
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Did not get an adequate effect from the standard 100 mg dose.
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Have a severe form of ED or resistance to lower dosages.
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Have good tolerability of Avanafil.
Key Advantages of Avanafil (Stendra)
Avanafil has two unique pharmacokinetic profiles:
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Ultra-Fast Start: This is the fastest PDE5 inhibitor. Due to rapid absorption, the effect can begin in as little as 15-20 minutes after intake (compared to 30-60 minutes for other drugs).
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High Selectivity: Avanafil acts very precisely on PDE5 and has significantly less effect on other PDE types (e.g., PDE6, found in the retina, or PDE11 in muscles).
Detailed Mechanism of Action of Stendra
The mechanism of action of Stendra is identical to other PDE5 inhibitors.
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Trigger: Sexual arousal causes the release of nitric oxide (NO).
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Erectile Cycle: NO stimulates the formation of cyclic GMP (cGMP), which relaxes the smooth muscles of the penile blood vessels, ensuring a powerful blood flow.
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PDE5 Blockade: Avanafil (at 200 mg) potently blocks the enzyme that degrades cGMP. Blocking this enzyme allows cGMP to persist longer, ensuring a stable, firm erection in response to stimulation.
Key takeaway: Stendra 200 mg provides a rapid "window" of readiness (about 6 hours), but sexual arousal is always required to achieve an erection.
Instructions for Using Stendra (200 mg)
Strict adherence to the instructions is necessary for safety and maximum efficacy.
Dosage and Timing of Intake
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Dosage: 200 mg (one tablet) – is the maximum single and daily dose.
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Frequency of Intake: Stendra should be taken no more than once per day.
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Method: Swallow the tablet whole with water.
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Timing: Take 15–30 minutes before planned sexual activity.
Influence of Food and Alcohol
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Food: Unlike Sildenafil, taking Stendra with a moderately high-fat meal does not significantly affect the onset of action.
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Alcohol: It is not recommended to combine Avanafil with excessive amounts of alcohol (more than 3 servings), as this can increase the risk of dropping blood pressure and dizziness.
Critical Contraindications
The list of contraindications related to the vasodilating effect is strict.
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Interaction with Nitrates: Absolutely forbidden! Taking Stendra with any form of organic nitrates (Nitroglycerin) or nitric oxide donors ("poppers") causes a life-threatening drop in blood pressure.
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Severe Cardiovascular Diseases: Recent heart attack or stroke (within 6 months), severe heart failure, unstable angina.
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Blood Pressure: Persistent hypotension (pressure < 90/50 mmHg) or uncontrolled hypertension.
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Liver and Kidneys: Severe hepatic or renal failure.
Side Effects of Avanafil (200 mg)
Taking the maximum 200 mg dose increases the risk of side effects, although due to high selectivity, they are still better tolerated than Sildenafil.
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Common: Headache, facial flushing, nasal congestion, dyspepsia.
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Specific: Avanafil very rarely causes visual disturbances ("blue haze") or the back and muscle pain sometimes seen with Sildenafil or Tadalafil.
Immediate medical attention is required for: An erection that lasts longer than 4 hours (priapism), or sudden loss of vision/hearing.
Professional Advice on Using
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Do Not Start with 200 mg: Stendra 200 mg is not a starting dose. Always start with 100 mg. The 200 mg dose is only for those who failed to respond to 100 mg.
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Hydration: To minimize headaches, drinking enough water on the day of intake is recommended.
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Not for Prolongation: Avanafil does not prolong intercourse and does not treat premature ejaculation. Combination drugs (like Super Avana) exist for this purpose.
Stendra 200 mg: Extended Q&A Section
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How long does Stendra 200 mg last? The erection effect lasts about 5-6 hours, regardless of the dose.
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What is the difference between Avanafil (200 mg) and Sildenafil (100 mg)? Avanafil acts much faster (15-20 min vs 45-60 min) and has a lower risk of side effects related to vision and muscles. The 200 mg dose of Avanafil is intended for those for whom 100 mg of Sildenafil was not strong enough.
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Can I take 200 mg daily? No. This is the maximum daily dose for "on-demand" use.
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Does Stendra prolong sexual intercourse? No. Avanafil is intended only for ED treatment.
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