SILDALIST

In modern therapy for erectile dysfunction (ED), men seek not only maximum potency but also flexibility, combining a rapid onset with a long duration of effect. SILDALIST is a unique combination generic containing two active PDE5 inhibitors: Sildenafil and Tadalafil. The drug is intended for men who require a quick onset of erection but also need the effect to last for an extended period.

What is SILDALIST?

SILDALIST is a highly effective Indian medication that combines two different active molecules in one tablet, each with its own unique profile of action:

1. Sildenafil Citrate (100 mg): Provides a powerful and rapid onset of action.

2. Tadalafil (20 mg): Ensures a long duration of effect ("the weekend pill").

This combination is not a standard therapeutic regimen but is in demand by those looking for the maximum extension of the "window" of sexual activity.

The unique dual mechanism of action of SILDALIST

The mechanism of action of SILDALIST combines the benefits of two different drugs that work by blocking the PDE5 enzyme.

1. Rapid and powerful start (Sildenafil 100 mg)

Sildenafil is quickly absorbed, reaching peak concentration in the blood in about an hour. This provides a fast and strong onset of erection in response to stimulation.

2. Long-term coverage (Tadalafil 20 mg)

Tadalafil has a much longer half-life (up to 17.5 hours) and a maximum duration of action of up to 36 hours. Tadalafil begins to act slower but maintains the relaxation of smooth vascular muscles over a prolonged period.

Combined Action: SILDALIST gives a fast effect thanks to Sildenafil while maintaining readiness for sexual activity over the following 24–36 hours due to Tadalafil.

Key takeaway: SILDALIST is designed to maximize the period during which a man can achieve an erection. Like all PDE5 inhibitors, it requires sexual arousal.

Instructions for using SILDALIST

Taking a drug with dual active ingredients requires maximum caution.

1. Dosage and timing of intake

• Dosage: One tablet of SILDALIST (100 mg Sildenafil + 20 mg Tadalafil) is the absolute maximum daily dose. It is strictly prohibited to take more than one tablet within 36 hours.

• Initial Dose: Never start with a whole tablet. Start with half a tablet (50 mg Sildenafil + 10 mg Tadalafil) to assess tolerability and avoid strong side effects.

• Method: Swallow the tablet whole with water.

• Timing: Take 45–60 minutes before the start of sexual activity.

2. Influence of food and alcohol

• Food: Taking SILDALIST with a fatty meal can delay the absorption of Sildenafil, postponing the rapid effect. It is recommended to take it on an empty stomach.

• Alcohol: Strongly discouraged. The combination of two powerful vasodilating drugs and alcohol can cause a sharp and severe drop in blood pressure, dizziness, headache, and an intensification of all side effects.

Critical contraindications for SILDALIST

The list of contraindications is amplified due to the summation of risks from the two molecules.

• Interaction with Nitrates: Absolutely forbidden! Taking SILDALIST with any form of organic nitrates (Nitroglycerin) or nitric oxide donors ("poppers") causes a life-threatening drop in blood pressure.

• Severe Cardiovascular Diseases: Recent heart attack or stroke, severe heart failure.

• Hypotension: Persistently low blood pressure (below 90/50 mmHg).

• Alpha-blocker intake: The combination requires extreme caution and is generally prohibited due to the risk of severe hypotension.

Side effects of SILDALIST

Side effects may include symptoms characteristic of both Sildenafil and Tadalafil. Tadalafil can cause myalgia (muscle aches) and back pain, while Sildenafil can cause headaches and visual disturbances.

• Common: Headache (very common), facial flushing, dyspepsia, nasal congestion.

• Specific: Muscle aches (due to Tadalafil), visual disturbances (due to Sildenafil).

Seek immediate medical attention if: An erection lasts longer than 4 hours (priapism), if there is sudden vision/hearing loss, or if there is severe chest pain.

Professional advice on using SILDALIST

1. Splitting is the key to safety: The SILDALIST tablet must be split. Start with half to assess the body's reaction to the combination of the two drugs.

2. Duration of Effect: Remember that the effect lasts up to 36 hours. Do not take the next dose during this period.

3. Special Cases: SILDALIST is suitable for long weekends or trips when daily tablet intake is inconvenient.

SILDALIST: Extended Q&A section

• Why does SILDALIST contain two different drugs? The combination is intended to provide the best of both worlds: the fast start of Sildenafil (which Tadalafil lacks) and the long duration of Tadalafil (which Sildenafil lacks).

• Can SILDALIST be taken daily? Absolutely not. Due to the high dosages of Sildenafil (100 mg) and Tadalafil (20 mg) and the long half-life, daily intake will cause a dangerously high accumulation of the drug in the bloodstream.

• What is the risk of combining Sildenafil and Tadalafil? The risk lies in the summation of side effects and the hypotensive effect (lowering of blood pressure). This can cause severe hypotension, especially in sensitive patients.

• Does SILDALIST prolong sexual intercourse? No. Neither Sildenafil nor Tadalafil affects the time to ejaculation. The drug is intended only for ED treatment.