Buy Vardenafil in Ukraine

Vardenafil: Review of the highly selective PDE5 inhibitor

Vardenafil is a highly effective medication for the treatment of erectile dysfunction (ED), belonging to the PDE5 inhibitor class. It is the active ingredient in the original drug Levitra, as well as numerous generics (e.g., VILITRA, ZHEWITRA, VALIF, SNOVITRA). Vardenafil is valued for its balanced action, rapid onset of effect, and, most importantly, its high selectivity, which ensures a favorable side effect profile.

What is Vardenafil and its place in ED therapy?

Vardenafil is a second-generation PDE5 inhibitor, developed after Sildenafil (Viagra). Its main goal was to improve upon some characteristics of its predecessor, particularly to reduce its impact on other enzymes (PDE6 and PDE11), thereby reducing the risk of specific side effects.

1. Indication and key advantages

Vardenafil is indicated for men who cannot achieve or maintain an erection sufficient for sexual intercourse.

Its key advantages are:

• High Selectivity: Vardenafil is many times more selective for PDE5 than for PDE6 (an enzyme in the retina). This means it very rarely causes vision-related side effects (like "blue haze") sometimes seen with Sildenafil.

• Rapid Onset of Action: The effect often begins faster than Sildenafil, usually within 25-60 minutes.

• Compatibility: It is considered the most "friendly" toward moderate alcohol consumption and is less dependent on fatty food.

• Efficacy in Difficult Groups: Vardenafil has shown high efficacy in patients with diabetes mellitus and in men post-prostatectomy.

Detailed mechanism of action of Vardenafil

The mechanism of action of Vardenafil is identical to other PDE5 inhibitors.

1. Trigger (Stimulation): The drug requires sexual arousal to work. During arousal, nerve endings in the penis release nitric oxide (NO).

2. Erectile Cycle: NO activates an enzyme that produces cyclic GMP (cGMP). cGMP is the key substance that relaxes the smooth muscles of the blood vessels in the corpus cavernosum.

3. Result (Engorgement): Muscle relaxation allows the vessels to widen, leading to a powerful inflow of blood and an erection.

4. PDE5 Blockade: Normally, the PDE5 enzyme quickly breaks down cGMP, and the erection subsides. Vardenafil blocks this enzyme. This allows cGMP to accumulate and last longer, ensuring a stable and firm erection.

Key takeaway: Vardenafil is not an aphrodisiac and does not cause a mechanical erection. It only enhances the natural physiological response to sexual stimulation.

Instructions for using Vardenafil (10 mg and 20 mg)

Strict adherence to the instructions is necessary for safety and maximum efficacy.

1. Dosage

• Starting Dose (10 mg): (e.g., VILITRA 10, ZHEWITRA 10). This is the recommended initial dose for most men. It provides an optimal balance of efficacy and safety. This dose is also recommended for men over 65.

• Maximum Dose (20 mg): (e.g., VILITRA 20, ZHEWITRA 20). This is the maximum daily dose. It is prescribed if 10 mg proves insufficient, and only after consulting a doctor.

It is strictly prohibited to take more than 20 mg of Vardenafil within 24 hours.

2. Method and time of intake

• Method: The tablet should be swallowed whole with water.

• Time of Intake: Take 30–60 minutes before planned sexual activity.

• Duration of Action: The effect lasts an average of 4-6 hours.

• Fast-Acting Forms: There are also jelly (Oral Jelly) or chewable (Soft) forms that start working faster (in 15-25 minutes) due to oral absorption.

3. Influence of food and alcohol

• Food: Vardenafil can be taken regardless of food. However, a very high-fat meal (over 55% fat) may slightly delay the onset of action.

• Alcohol: Vardenafil is considered the most alcohol-compatible PDE5 inhibitor. Moderate doses of alcohol (e.g., a glass of wine) do not usually affect the drug's action. However, excessive alcohol use itself inhibits erectile function.

Critical contraindications

The list of contraindications related to the vasodilating effect is strict.

• Interaction with Nitrates: Absolutely forbidden! Taking Vardenafil with any form of organic nitrates (Nitroglycerin, isosorbide dinitrate) or nitric oxide donors ("poppers") causes a life-threatening drop in blood pressure.

• Severe Cardiovascular Diseases: Recent heart attack or stroke (within 6 months), severe heart failure, unstable angina.

• Blood Pressure: Persistent hypotension (pressure < 90/50 mmHg) or uncontrolled hypertension.

• Alpha-blockers: (for BPH) – requires caution and medical advice.

• Severe hepatic or renal impairment.

• Congenital QT prolongation on an ECG.

Side effects of Vardenafil

Vardenafil is generally well-tolerated. Side effects (if they occur) are usually mild and temporary.

• Common: Headache (most common), facial flushing, nasal congestion, dyspepsia (indigestion).

• Rare: Dizziness, back pain (significantly less common than with Tadalafil).

• Very Rare: Visual disturbances (due to high selectivity for PDE5).

Seek immediate medical attention if: An erection lasts longer than 4 hours (priapism), or if you experience sudden vision/hearing loss.

Professional advice on using

1. Pill Splitting: High-dose generics (e.g., VILITRA 40 or VILITRA 60) are not intended to be taken whole. They are designed for economy – they are split into 2-4 parts to get standard 10 mg or 20 mg doses.

2. Choice for Diabetics: If you have diabetes, Vardenafil is often the drug of choice, as it has shown high efficacy in this patient group.

3. Not for Prolongation: Vardenafil does not affect the time to ejaculation. For treating both ED and PE, combination drugs are used (e.g., Super Vilitra, containing Vardenafil + Dapoxetine).

Vardenafil: Extended Q&A section

• How does Vardenafil (20 mg) differ from Sildenafil (100 mg)? These doses are roughly equivalent in strength. Vardenafil acts slightly faster, is less affected by food, and has a significantly lower risk of visual side effects.

• How does Vardenafil (20 mg) differ from Tadalafil (20 mg)? The main difference is duration. Vardenafil lasts 4-6 hours; Tadalafil lasts up to 36 hours. However, Tadalafil is more likely to cause back pain and muscle aches.

• What if 10 mg didn't work? Ensure you took the drug 30–60 minutes prior and had sufficient sexual stimulation. If the effect is insufficient, consult your doctor about switching to 20 mg.