POXET 30

Premature ejaculation (PE) is one of the most common male sexual dysfunctions. POXET 30 is a medication containing 30 mg of Dapoxetine, which is the standard and recommended initial dose for the treatment of PE. This dosage provides significant control over ejaculation with a minimal risk of side effects.

What is POXET 30?

POXET 30 is a generic medication whose active substance is Dapoxetine Hydrochloride. Dapoxetine is the only drug specifically designed and approved for PE treatment, belonging to the Selective Serotonin Reuptake Inhibitor (SSRI) class, but with an ultra-short duration of action.

1. Indication and purpose of the dosage

The drug is intended for the treatment of PE in men aged 18–64. POXET 30 is the ideal starting dose:

• Efficacy: 30 mg of Dapoxetine is proven to increase the Intravaginal Ejaculatory Latency Time (IELT) by 3–4 times.

• Safety: The 30 mg dose has the most favorable tolerability profile, with the lowest likelihood of side effects such as nausea and dizziness.

Detailed mechanism of action of POXET 30

The mechanism of action of POXET 30 is linked to the neurochemistry of the brain and the control of the ejaculation reflex.

1. Serotonin and Reflex: Serotonin (5-HT) is a key inhibitory neurotransmitter regulating the ejaculatory reflex. Rapid serotonin utilization is associated with premature ejaculation.

2. Action of Dapoxetine: Dapoxetine blocks the transporter proteins that carry out the reuptake of serotonin in neurons. This leads to a temporary and rapid increase in serotonin concentration in the synaptic cleft.

3. Result: The enhancement of serotonergic transmission exerts an inhibitory effect on the brain and spinal cord centers that control ejaculation. This slows down nerve impulses and allows the man to significantly prolong sexual intercourse.

Key takeaway: The ultra-short action of Dapoxetine allows POXET 30 to be taken "on-demand" without the drug accumulating in the body, which is typical of conventional SSRIs.

Instructions for using POXET 30

Strict adherence to the rules for taking POXET 30 is crucial for safety, especially to minimize the risk of fainting (syncope).

1. Dosage and timing of intake

• Dosage: 30 mg (one tablet) is the standard initial dose unit.

• Dose Increase: If POXET 30 is well-tolerated but the effect is insufficient, the dose can be increased to 60 mg after consulting a doctor. The maximum daily dose is 60 mg.

• Method: Swallow the tablet whole with a full glass (at least 250 ml) of water. Do not chew.

• Timing: Take 1–3 hours before planned sexual activity.

2. Influence of alcohol

• Alcohol: Absolute prohibition. The combination of Dapoxetine with alcohol manifold increases the risk of neurocognitive side effects (dizziness, drowsiness) and can lead to fainting (syncope) and toxic liver damage.

Critical contraindications for POXET 30

Even at the minimum dose, the drug has strict contraindications.

• Cardiovascular Disorders: Cardiac rhythm disturbances, severe heart failure, IHD (Ischemic Heart Disease).

• Hepatic Impairment: Severe and moderate severity.

• Psychiatric Disorders: History of mania, severe depression, uncontrolled bipolar disorder.

• Drug Interactions: Absolutely forbidden to take with:

  • MAO Inhibitors (MAOIs): Risk of serotonin syndrome.

  • Potent CYP3A4 Inhibitors: (Ketoconazole, Erythromycin, Grapefruit juice). Increases Dapoxetine concentration and the risk of fainting.

  • Other SSRIs: (Antidepressants).

Side effects of POXET 30 (Minimal risk)

The 30 mg dose has the most favorable side effect profile among all Dapoxetine dosages.

• Very Common (but mild): Nausea (the most common side effect), dizziness, headache.

• Common: Drowsiness, insomnia, anxiety, dry mouth.

Special Warning: To avoid fainting (syncope), which is a rare but dangerous side effect, always wash the tablet down with a full glass of water and avoid dehydration.

Professional advice on using POXET 30

1. Take while sitting or standing: To minimize the risk of fainting (orthostatic hypotension), take POXET 30 while standing, washing it down with a full glass of water. Avoid standing up abruptly after intake.

2. Not for daily use: Dapoxetine is an "on-demand" drug. It should not be taken daily or as a course.

3. Combination Therapy: If you have both PE and ED, POXET 30 can be safely combined with PDE5 inhibitors (Sildenafil, Tadalafil) for a dual effect (PE control + firm erection), provided contraindications are strictly excluded.

POXET 30: Extended Q&A section

• How much does POXET 30 prolong intercourse? On average, IELT (latency time) increases by 3–4 times. This is often sufficient to increase satisfaction.

• How soon does POXET 30 start working? The effect begins to manifest after 60 minutes, with the peak effect occurring 1–2 hours after intake.

• How long does the prolongation effect last? The ejaculation control effect lasts for 3–4 hours after the peak concentration, which is optimal for "on-demand" use.

• Can the POXET 30 tablet be split? No. The film-coated tablet must be swallowed whole. If a smaller dose is needed (e.g., 15 mg), a drug with a lower initial dose should be chosen.