SILDIGRA 100

In the treatment of erectile dysfunction (ED), SILDIGRA 100 is one of the most popular generics, containing 100 mg of Sildenafil Citrate. This dosage is recognized as the maximum standard daily dose, providing the highest efficacy for the vast majority of men with moderate to severe ED.

What is SILDIGRA 100?

SILDIGRA 100 is an oral tablet medication containing the full therapeutic dose of Sildenafil (100 mg), the active ingredient of the original Viagra.

1. Indication and target audience

The drug is intended for the treatment of ED when a man cannot achieve or maintain an erection sufficient for satisfactory sexual intercourse. The 100 mg dose is suitable for men who:

• Did not achieve a sufficient therapeutic response from the initial 50 mg Sildenafil dose.

• Have moderate or severe ED and require a guaranteed maximum effect.

• Have good tolerability to the drug.

2. Importance of the dosage

100 mg is the maximum dose recommended for regular intake. SILDIGRA 100 is not recommended for first-time use; doctors advise starting therapy with 50 mg. If 50 mg is insufficient, the dose is increased to 100 mg.

Detailed mechanism of action of SILDIGRA 100

The mechanism of action of SILDIGRA 100 is based on the potent inhibition of the phosphodiesterase type 5 (PDE5) enzyme.

1. Trigger: The drug requires sexual stimulation to work, which causes the local release of nitric oxide (NO).

2. Erectile Cycle: NO stimulates the formation of cyclic GMP (cGMP). cGMP is the substance that relaxes the smooth muscles of the penile blood vessels.

3. PDE5 Blockade: Sildenafil 100 mg blocks the enzyme that degrades cGMP. This prolongs the action of cGMP, leading to a powerful blood flow to the corpus cavernosum and ensuring a stable, firm, and sustained erection.

Key takeaway: SILDIGRA 100 only works when sexual arousal is present. It is not an aphrodisiac.

Instructions for using SILDIGRA 100

Strict adherence to the rules for taking SILDIGRA 100 is necessary for safety and efficacy.

1. Dosage and timing of intake

• Dosage: 100 mg (one tablet) is the maximum daily dose. It is strictly prohibited to take more than 100 mg within 24 hours.

• Starting Dose: Start intake with 50 mg (half a tablet) if you are a new user.

• Method: The tablet should be swallowed whole with a full glass of water.

• Timing: Take 45-60 minutes before planned sexual activity. The effect lasts 4-6 hours.

2. Influence of food and alcohol

• Food: Taking SILDIGRA 100 with a heavy, fatty meal can significantly delay the onset of action (up to 90 minutes or more), as absorption occurs in the stomach. For a faster effect, take it on an empty stomach or after a light meal.

• Alcohol: It is not recommended to combine Sildenafil intake with excessive amounts of alcohol, as this can enhance the vasodilating effect and increase the risk of dizziness and a drop in blood pressure.

Critical contraindications for SILDIGRA 100

The list of contraindications must be reviewed with a doctor before initiating therapy.

• Interaction with Nitrates: Absolutely forbidden to take SILDIGRA 100 with any form of organic nitrates (Nitroglycerin) or nitric oxide donors ("poppers"). This combination causes a critical, life-threatening drop in blood pressure.

• Severe Cardiovascular Diseases: Recent myocardial infarction or stroke (within 6 months), unstable angina, severe heart failure.

• Blood Pressure: Persistent hypotension (pressure < 90/50 mmHg).

• Liver and Kidneys: Severe hepatic or renal failure.

• Eyes: Hereditary degenerative retinal diseases (retinitis pigmentosa).

Side effects of SILDIGRA 100

At the 100 mg dose, side effects occur more frequently and can be more pronounced than at 50 mg.

• Very Common: Headache (the most common effect).

• Common: Facial flushing, nasal congestion, dyspepsia (indigestion).

• Less Common: Visual disturbances (temporary change in color perception, "blue haze," light sensitivity), dizziness.

Immediate medical attention is required for: An erection that lasts longer than 4 hours (priapism), or sudden loss of vision/hearing.

Professional advice on using SILDIGRA 100

1. Splitting the Tablet: The SILDIGRA 100 tablet can be easily split in half to obtain a 50 mg dose. This offers the flexibility to find the minimum effective dose, minimizing side effects.

2. Regular Assessment: If 100 mg causes frequent side effects, it is advisable to revert to 50 mg or consider switching to Vardenafil or Tadalafil, which have a different side effect profile.

3. Hydration: Sildenafil can cause headaches due to vasodilation. It is recommended to drink enough water throughout the day of intake.

SILDIGRA 100: Extended Q&A section

• How much more effective is SILDIGRA 100 than 50 mg? Efficacy increases, but not linearly. The increase in effectiveness is most noticeable in men who did not respond to the 50 mg dose at all.

• How long does SILDIGRA 100 last? The duration of action of Sildenafil 100 mg averages 4-6 hours.

• Can SILDIGRA 100 be taken with grapefruit juice? No. Grapefruit juice is a CYP3A4 inhibitor, which can significantly increase the concentration of Sildenafil in the blood, enhancing its action and the risk of side effects. This is strongly discouraged.

• Does SILDIGRA 100 prolong sexual intercourse? No. Sildenafil is intended only for ED treatment and does not affect the time to ejaculation. Medications containing Dapoxetine are used for prolongation.