Tadalafil 60 mg: Ultra-high dose for maximum economy
Tadalafil 60 mg (e.g., in generics like Vidalista 60, Tadadel 60) is a medication containing 60 mg of Tadalafil. This dosage is triple the maximum standard dose ("the weekend pill"). It is crucial to understand that this dosage is categorically not intended for a single intake. The primary purpose of Tadalafil 60 mg is to provide patients with an economical way to obtain multiple standard doses (20 mg) or starting doses (10 mg) by splitting the tablet.
What is Tadalafil 60 mg?
Tadalafil 60 mg is a generic containing 60 mg of Tadalafil. Tadalafil is a PDE5 inhibitor with a unique duration of action of up to 36 hours.
Indication and dosage warning
It must be strictly understood: the standard maximum daily dose of Tadalafil approved by regulatory bodies is 20 mg. The 60 mg dosage offered by this drug triples this standard.
This medication should never be used for taking a whole tablet at once. It is intended for:
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Economy: Splitting the 60 mg tablet into 3 parts (20 mg each) or 6 parts (10 mg each) significantly reduces the cost of treatment.
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Severe ED: In very rare, resistant cases, a doctor might prescribe a higher dose, but 60 mg at once is an extremely high load on the body.
Detailed mechanism of action of Tadalafil (36 hours)
The mechanism of action of Tadalafil 60 mg is based on Tadalafil being a potent and selective inhibitor of the PDE5 enzyme.
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Trigger: Sexual arousal causes the release of nitric oxide (NO).
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Erectile Cycle: NO stimulates the formation of cyclic GMP (cGMP), which relaxes the smooth muscles of the penile blood vessels, ensuring blood flow.
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PDE5 Blockade: Tadalafil blocks the PDE5 enzyme that degrades cGMP. Blocking this enzyme allows cGMP to persist longer, ensuring a stable erection.
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Duration: Tadalafil's half-life (17.5 hours) provides a "window" of efficacy for up to 36 hours.
Key takeaway: Tadalafil 60 mg provides a prolonged "window" of readiness, but sexual arousal is always required to achieve an erection.
Instructions for using Tadalafil 60 mg: Safety rules
Taking a dose as high as 60 mg requires extreme caution and monitoring.
Dosing recommendations
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Initial Use: It is strictly forbidden to start treatment with a whole 60 mg tablet. Always start with 1/6 of a tablet (10 mg).
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Standard Maximum Dose: 1/3 of a tablet (20 mg).
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Maximum Daily Dose: Do not take more than 20 mg (1/3 of a tablet) within 24–36 hours.
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Method: Swallow the tablet whole with water.
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Timing: Take 30–60 minutes before planned sexual activity.
Interaction with food and alcohol
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Food: Tadalafil 60 mg can be taken regardless of food.
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Alcohol: Combining 60 mg of Tadalafil and alcohol is not recommended, as it can increase the risk of dropping blood pressure and dizziness.
Critical contraindications
Due to the increased dosage, the risks of interaction are heightened.
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Interaction with Nitrates: Absolutely forbidden! Taking Tadalafil 60 mg with any form of nitrates or nitric oxide donors (e.g., Nitroglycerin) causes a life-threatening drop in blood pressure.
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Severe Cardiovascular Diseases: Recent heart attack or stroke (within 6 months), unstable angina, severe heart failure.
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Blood Pressure: Persistent hypotension (pressure < 90/50 mmHg) or uncontrolled hypertension.
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Liver and Kidneys: Severe hepatic or renal failure.
Side effects of Tadalafil 60 mg: Increased Risk
At a 60 mg dosage (if the whole tablet is taken), the probability and intensity of side effects increase manifold.
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Very Common: Severe headache, dyspepsia, pronounced back pain and muscle aches (myalgia), flushing.
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Increased Risk of Serious Effects: Priapism (painful erection lasting longer than 4 hours), sudden loss of vision or hearing, severe hypotension.
Professional advice on using
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Splitting is the key to safety and economy: Tadalafil 60 mg is ideal for splitting. By dividing it into three parts, you get three maximum standard doses of 20 mg. This gives maximum efficacy with lower risk.
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Do not chase the dose: If 20 mg of Tadalafil provides a sufficient effect, switching to 40 mg or 60 mg will not increase the duration of the erection (it remains up to 36 hours), but will sharply increase the risk of adverse reactions.
Tadalafil 60 mg: Extended Q&A section
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How long does Tadalafil 60 mg last? The duration of Tadalafil's action does not depend on the dose. The effect is maintained for up to 36 hours.
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Can I take Tadalafil 60 mg if 20 mg did not work? The transition to a higher dose is only possible after consulting a doctor. Always start with 1/3 of a tablet (20 mg) to assess tolerability.
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How does Tadalafil differ from Sildenafil? Tadalafil (the active substance in Tadalafil 60 mg) acts for up to 36 hours, Sildenafil acts for 4-6 hours.
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Is a doctor's consultation required before taking 60 mg? Yes, it is mandatory. The 60 mg dose is three times the therapeutic maximum.
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