MALEGRA 150

In most cases, the standard maximum dose of Sildenafil (100 mg) is sufficient for the effective treatment of erectile dysfunction (ED). However, for men with severe or resistant forms of erectile impairment, or for those who did not get the desired response from 100 mg, pharmacology offers enhanced generics. MALEGRA 150 is a medication containing an increased dose of Sildenafil Citrate (150 mg).

What is MALEGRA 150?

MALEGRA 150 is a highly concentrated Sildenafil generic, manufactured in India. Each tablet contains 150 mg of the active compound.

1. Indication and placement of the medication in therapy

The drug is intended for the treatment of erectile dysfunction, manifested as the inability to achieve or maintain an erection sufficient for satisfactory sexual intercourse. MALEGRA 150 is not an initial dose and should only be used in cases where the standard 100 mg dose proved insufficient.

It must be emphasized that the 150 mg dosage exceeds the official maximum daily dose of Sildenafil (100 mg) recommended by most health regulatory bodies globally. This dose is typically used for patients with severe vascular impairments, for men with high body mass (above 100-120 kg), or as "salvage therapy" after the ineffectiveness of 100 mg.

Detailed mechanism of action of MALEGRA 150

Sildenafil is a potent, highly selective inhibitor of the phosphodiesterase type 5 (PDE5) enzyme. To understand the action of MALEGRA 150, one needs to know the physiology of an erection.

Upon sexual arousal, nerve endings release nitric oxide (NO). NO stimulates the production of cyclic Guanosine Monophosphate (cGMP). cGMP relaxes the smooth muscles of the arteries, leading to their widening (vasodilation) and a powerful inflow of blood, causing an erection.

The PDE5 enzyme breaks down cGMP, concluding the erection. Sildenafil blocks PDE5. The 150 mg dose provides a high concentration of the inhibitor, allowing cGMP to persist longer in the tissues. This dramatically enhances the natural response to sexual stimulation, leading to a firmer and more sustained erection.

Key takeaway: The medication acts as a catalyst. Without sexual arousal, there will be no erection.

Instructions for using MALEGRA 150: Risk assessment

Since 150 mg is an elevated dose, adherence to instructions and risk assessment are critically important.

1. Dosing and administration recommendations

• Initial Dose: Never start treatment with MALEGRA 150! Always begin with 50 mg, then progress to 100 mg if necessary. Taking 150 mg is only permissible after 100 mg has been ineffective.

• Taking a Full Tablet: Take one tablet (150 mg) with water.

• Timing: Take 45-60 minutes before intercourse. The effect lasts 4-6 hours.

• Restriction: Do not exceed 150 mg within a 24-hour period.

2. Influence of food and alcohol

• Food: Taking MALEGRA 150 with food, especially fatty meals, sharply slows down the absorption of Sildenafil and delays the onset of action by 1-2 hours. For maximum efficacy, it is recommended to take it on an empty stomach.

• Alcohol: Alcohol is a vasodilator and, combined with Sildenafil, increases the risk of hypotension (drop in blood pressure), dizziness, and headache. Alcohol should be completely excluded when taking 150 mg.

Critical contraindications for MALEGRA 150

The increased 150 mg dose carries higher risks, so contraindications must be adhered to particularly strictly.

1. Drug Interaction: Concurrent use of NITRATES or nitric oxide donors (e.g., nitroglycerin) is strictly prohibited. This causes a fatally dangerous drop in blood pressure.

2. Cardiovascular System: Contraindications include a recent myocardial infarction or stroke (within 6 months), unstable angina, and severe heart failure, as these carry the risk of cardiovascular collapse.

3. Eyes: Diagnosed hereditary degenerative retinal disorders (e.g., retinitis pigmentosa) increase the risk of Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION).

4. Other Conditions: Severe liver or kidney failure, hypotension (persistent blood pressure below 90/50 mmHg), and a confirmed allergy to Sildenafil.

Side effects of MALEGRA 150: What you need to know

As clinical trials of high-dose Sildenafil have shown, increasing the dose above 100 mg does not lead to a linear increase in efficacy but drastically increases the frequency and severity of side effects.

1. Common adverse reactions (likelihood is higher than with 100 mg):

• Headache (very common): The most frequent side effect due to vasodilation.

• Flushing: Redness of the face, neck, and feeling of warmth.

• Visual disturbances: Includes blurred vision, increased light sensitivity (photophobia), and temporary changes in color perception ("blue haze" in vision).

• Nasal congestion.

• Dyspepsia, nausea.

2. Immediate medical attention is required for:

• An erection lasting more than 4 hours (priapism). This condition can lead to irreversible damage to penile tissues.

• Sudden loss of vision in one or both eyes.

• Sudden decrease or loss of hearing.

• Chest pain, which may indicate heart issues.

Professional advice on using MALEGRA 150

1. Pill Splitting for safety and economy: MALEGRA 150 is an excellent choice for splitting. The tablet can be divided into three parts of 50 mg or two parts of 75 mg. This allows you to find the minimum effective dose, minimize side effects, and be more economical.

2. Gradual approach: Start with a dose no higher than 75 mg. If this level does not yield the desired result and is well-tolerated, only then proceed to a full tablet (150 mg).

3. Not for daily use: Sildenafil, including MALEGRA 150, is intended for "on-demand" use (no more than once every 24 hours). Other medications (e.g., Tadalafil 5 mg) exist for daily maintenance therapy.

MALEGRA 150: Extended Q&A section

• How much more effective is 150 mg than 100 mg? Clinical data show that the increase in efficacy between 100 mg and 150 mg is marginal, while side effects increase noticeably. The main gain in effectiveness from MALEGRA 150 is felt by men with severe ED for whom 100 mg was ineffective.

• What is the difference between MALEGRA 150 and MALEGRA 100? The difference is in the concentration of the active substance (150 mg versus 100 mg). MALEGRA 150 has a higher potential for effectiveness but also a higher risk of side effects.

• Does MALEGRA 150 prolong sexual intercourse? No. Sildenafil (any dose) is intended only for the treatment of ED (erectile dysfunction) and does not affect the time to ejaculation. Medications containing Dapoxetine or Duloxetine are used to solve the problem of premature ejaculation (PE).

• How fast does MALEGRA 150 work and how long does the effect last? The action begins after 45-60 minutes. Efficacy is maintained for 4-6 hours.