MALEGRA 100

Erectile Dysfunction (ED) is a common problem that requires reliable and effective treatment. MALEGRA 100 is one of the most popular generics, containing 100 mg of Sildenafil Citrate. This dosage is recognized as the maximum standard daily dose, providing the highest efficacy for the vast majority of men.

What is MALEGRA 100 and who is it indicated for?

MALEGRA 100 is a high-quality Indian generic that contains the full therapeutic dose of Sildenafil (100 mg).

1. Indication and target audience

The drug is intended for the treatment of ED when a man cannot achieve or maintain an erection sufficient for satisfactory sexual intercourse. The 100 mg dose is suitable for men who:

• Did not achieve a sufficient therapeutic response from the initial 50 mg dose.

• Have moderate or severe ED, where 100 mg is required for a guaranteed effect.

• Have normal tolerability to Sildenafil.

2. Comparison with other doses

100 mg is the maximum dose recommended for regular use. Starting therapy immediately with MALEGRA 100 is not recommended; doctors advise trying 50 mg first to assess tolerability and efficacy with minimal side effects. If 50 mg is insufficient, the dose is increased to 100 mg.

Detailed mechanism of action of MALEGRA 100

The mechanism of action of MALEGRA 100 is based on the potent inhibition of the PDE5 enzyme.

1. Trigger: The effect is triggered only by sexual arousal, when nerve impulses release nitric oxide (NO).

2. Erectile Response: NO stimulates the production of cyclic Guanosine Monophosphate (cGMP). cGMP causes the relaxation of smooth muscles in blood vessels (vasodilation), which ensures a rapid and abundant blood flow to the corpus cavernosum of the penis.

3. PDE5 Blockade: The PDE5 enzyme normally breaks down cGMP. Sildenafil 100 mg blocks this enzyme, allowing cGMP to maintain a high concentration. This leads to the enhancement, stabilization, and prolongation of the natural erection.

Key takeaway: Taking MALEGRA 100 provides the maximum physiological response but will not replace sexual desire.

Instructions for using MALEGRA 100

Strict adherence to the rules for taking MALEGRA 100 is necessary for safety and efficacy.

1. Dosage and timing

• Dosage: 100 mg (one tablet) is the maximum daily dose. It is strictly prohibited to take more than 100 mg within 24 hours, as this will not lead to a better effect but will sharply increase the side effect risks.

• Time of Intake: The tablet should be swallowed whole with water approximately 45-60 minutes before the start of sexual intercourse.

2. Influence of food and alcohol

• Food: Taking MALEGRA 100 with a rich, fatty meal (e.g., after a heavy dinner) can significantly delay the onset of action (up to 90-120 minutes), as absorption occurs in the stomach. For a fast effect, take it on an empty stomach.

• Alcohol: Excessive alcohol consumption is not recommended, as it both reduces erectile function itself and enhances the vasodilating effect of Sildenafil, increasing the risk of dizziness and a drop in blood pressure.

Critical contraindications for MALEGRA 100

The list of contraindications must be reviewed with a doctor before initiating therapy.

• Interaction with Nitrates: It is absolutely forbidden to take MALEGRA 100 with any form of nitrates (Nitroglycerin, isosorbide dinitrate) or nitric oxide donors ("poppers"). This combination causes a critical, life-threatening drop in blood pressure.

• Severe Cardiovascular Diseases: Recent myocardial infarction or stroke (within 6 months), severe heart failure, unstable angina.

• Severe Liver or Kidney Failure.

• Hypotension: Persistently low blood pressure (below 90/50 mmHg).

• Allergy to Sildenafil or other components.

Side effects of MALEGRA 100

At the 100 mg dose, side effects are more frequent and pronounced than at 50 mg. They are generally temporary and easily managed.

• Very Common: Headache (the most common effect).

• Common: Facial flushing, nasal congestion, dyspepsia (indigestion).

• Less Common: Visual disturbances (temporary change in color perception, light sensitivity, blurred vision), dizziness.

Seek immediate medical attention if: An erection lasts longer than 4 hours (priapism) or if there is sudden vision/hearing loss.

Professional advice on using MALEGRA 100

1. Splitting the Tablet: If you purchase MALEGRA 100 and wish to start with a lower dose, the tablet can be easily split into two 50 mg halves. This provides dosing flexibility and allows you to find the minimum effective dose.

2. Not for Daily Therapy: MALEGRA 100 is intended for "on-demand" use. For men requiring daily support, low-dose Tadalafil preparations are generally a better choice.

3. Psychological Factor: Use the confidence the drug provides to overcome psychological barriers. Many men who successfully complete therapy can eventually reduce their dosage or manage without it.

MALEGRA 100: Extended Q&A section

• How long does MALEGRA 100 last? The effect of 100 mg Sildenafil lasts for an average of 4-6 hours. During this time, you can achieve multiple erections in response to sexual stimulation.

• If 100 mg doesn't work, what should I do? If after several attempts (following all rules: on an empty stomach, with arousal) there is no effect, you should consult a urologist. The doctor may check absorption or recommend switching to another class of PDE5 inhibitors (e.g., Tadalafil or Vardenafil). Self-increasing the dose above 100 mg of MALEGRA 100 (or buying 150/200 mg) is highly discouraged due to increased risks.

• What is the difference between MALEGRA 100 and standard Viagra 100 mg? The active substance (Sildenafil 100 mg) is absolutely identical. The difference lies in the manufacturer (MALEGRA is an Indian generic) and, typically, a more accessible price.

• Does the drug cause dependence? Sildenafil does not cause physical dependence. However, some men may develop psychological dependence (fear of failure without the pill).