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Tadalafil +: Combination for Long-Lasting Erection and Control (Tadalafil + Dapoxetine)

The term Tadalafil + (or "Super" Tadalafil, e.g., Super Vidalista, Super Tadarise, Tadopox) is a common name for a category of combination generics designed for men who simultaneously face two problems: erectile dysfunction (ED)and premature ejaculation (PE).

These drugs combine two powerful active ingredients with entirely different mechanisms of action in one tablet.

What is in Tadalafil +?

Usually, when referring to "Super" or "+" drugs, the following standard combination is implied:

1. Tadalafil (20 mg): This is the main erection component (Cialis analogue). It is a PDE5 inhibitor and is responsible for achieving and maintaining a firm erection with a duration of action of up to 36 hours.

2. Dapoxetine (60 mg): This is the "+" component. It is a short-acting Selective Serotonin Reuptake Inhibitor (SSRI) and is responsible for control and prolongation of intercourse.

Popular brand names for such drugs include: Super Vidalista, Super Tadarise, Tadacip D, Super Tadadel, Tadopox, and others.

Dual Mechanism of Action

The drug acts simultaneously on the vascular and neurochemical systems.

1. How Tadalafil (20 mg) works

Tadalafil does not cause an erection mechanically. It works only in the presence of sexual stimulation. It blocks the PDE5 enzyme, which leads to the relaxation of blood vessels in the penis and a powerful inflow of blood, ensuring a stable erection for up to 36 hours.

2. How Dapoxetine (60 mg) works

Dapoxetine acts on the central nervous system. It temporarily increases serotonin levels in the brain, which has an inhibitory effect on the ejaculation centers. This allows the man to better control the moment of orgasm and significantly prolongs intercourse (by 3-4 times on average).

Key takeaway: Tadalafil + provides a unique combined effect: Tadalafil ensures long-lasting readiness (up to 36 hours), and Dapoxetine allows for significantly prolonged intercourse.

Instructions for Use: Very Important!

Taking a combination drug requires strict adherence to the rules due to the presence of two potent active components.

1. Dosage

• One tablet (20 mg Tadalafil + 60 mg Dapoxetine) is the absolute maximum dose.

• Frequency of Intake: No more than once every 24-36 hours (due to the long half-life of Tadalafil).

• Initial Dose: Never start with a whole tablet. It is recommended to start with 1/2 a tablet (10 mg Tadalafil + 30 mg Dapoxetine) to assess tolerability.

2. Time and Method of Intake

• Time of Intake: Take 1–3 hours before planned sexual activity.

• Why so early? Tadalafil starts working in 30-60 minutes, but Dapoxetine needs time (1-2 hours) to reach peak concentration and maximum prolongation effect.

• Method: Swallow the tablet (or its part) whole with a full glass (at least 250 ml) of water.

Critical Contraindications and Warnings

The list of contraindications is amplified due to the summation of risks from the two molecules.

1. ALCOHOL: ABSOLUTE PROHIBITION!

• This is the most important rule. Dapoxetine (the "+" component) is absolutely incompatible with alcohol. Their combination manifold increases the risk of neurocognitive side effects (dizziness, drowsiness) and can lead to fainting (syncope), which is dangerous.

2. INTERACTION WITH NITRATES: FATAL!

• Tadalafil (the ED component) is strictly forbidden to take with any form of organic nitrates (Nitroglycerin, isosorbide dinitrate – heart medications) or nitric oxide donors ("poppers"). This causes a life-threatening drop in blood pressure.

3. Other Contraindications

• Severe cardiovascular diseases (recent heart attack or stroke).

• Taking antidepressants (other SSRIs) or MAO inhibitors.

• Severe liver or kidney failure.

Side Effects of Tadalafil +

Side effects can be caused by either of the two components.

• From Tadalafil: Headache, dyspepsia, back pain and muscle aches (myalgia), facial flushing.

• From Dapoxetine: Nausea (most common effect), dizziness, drowsiness, dry mouth.

Professional Advice on Use

1. Splitting is Safety: Start with 1/2 tablet. If 10 mg of Tadalafil and 30 mg of Dapoxetine provide a sufficient effect, there is no need to take the full dose and increase the risks.

2. Take with Water, While Seated: To minimize the risk of fainting, always take the drug while standing or sitting, with a full glass of water, and avoid standing up abruptly.

3. Not for Daily Use: This is an "on-demand" drug. It is not intended for daily course intake.

Tadalafil +: Extended Q&A Section

• How long does the effect last? The erection effect (Tadalafil) lasts up to 36 hours. The prolongation effect (Dapoxetine) lasts for 4–6 hours. This means you can have multiple sexual encounters over 36 hours, but the maximum PE control will be in the first 4-6 hours.

• What if I only have ED, but not PE? In this case, taking Dapoxetine is unnecessary. Use pure Tadalafil (e.g., Vidalista 20).

• What if I only have PE, but not ED? Use pure Dapoxetine (e.g., Vriligy, Poxet).