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Udenafil: Review of the PDE5 inhibitor for sustained erection

Udenafil is a modern medication for the treatment of erectile dysfunction (ED), belonging to the PDE5 inhibitor class. It is the active ingredient in drugs like ZUDENA or UDAFORCE. Udenafil is often called the "golden mean" between Sildenafil (Viagra) and Tadalafil (Cialis), as it combines a rapid onset of action with a significantly prolonged period of efficacy (up to 24 hours).

What is Udenafil?

Udenafil is a selective PDE5 enzyme inhibitor developed for the treatment of ED. It was approved for use in Korea in 2005 and has since gained popularity in many countries as an effective and reliable active ingredient.

1. Indication and dosage

The drug is intended for men who cannot achieve or maintain an erection sufficient for sexual intercourse.

• Standard Dose: 100 mg. This is the recommended starting and therapeutic dose for most men.

• Maximum Dose: 200 mg. This is used only in cases where 100 mg proved insufficient, and only after consulting a doctor.

2. Key advantages of Udenafil

Udenafil has a unique pharmacokinetic profile that gives it advantages:

• Rapid Start: Action begins relatively quickly, within 30–60 minutes.

• Sustained Effect: Udenafil's half-life (11-13 hours) provides a "window" of efficacy for up to 24 hours. This is significantly longer than Sildenafil (4-6 hours) but shorter than Tadalafil (36 hours).

• Food Independence: Udenafil is minimally affected by fatty foods, which enhances spontaneity.

Detailed mechanism of action of Udenafil

The mechanism of action of Udenafil is identical to other PDE5 inhibitors.

1. Trigger: Sexual arousal causes the release of nitric oxide (NO).

2. Erectile Cycle: NO stimulates the formation of cyclic GMP (cGMP), which relaxes the smooth muscles of the penile blood vessels, ensuring a powerful blood flow.

3. PDE5 Blockade: Udenafil blocks the enzyme that degrades cGMP. Blocking this enzyme allows cGMP to persist longer, ensuring a stable, firm erection in response to stimulation.

Key takeaway: Udenafil provides a prolonged "window" of readiness, but sexual arousal is always required to achieve an erection.

Instructions for using Udenafil (100 mg)

Strict adherence to the instructions is necessary, considering the drug's long duration of action.

1. Dosage and timing of intake

• Dosage: 100 mg (one tablet) – is the standard single dose.

• Frequency of Intake: Due to its long action (up to 24 hours), Udenafil should be taken no more than once per day.

• Method: Swallow the tablet whole with water.

• Timing: Take 30–60 minutes before planned sexual activity.

2. Influence of food and alcohol

• Food: Udenafil can be taken regardless of food.

• Alcohol: It is not recommended to combine Udenafil with excessive amounts of alcohol, as it can increase the risk of dropping blood pressure and dizziness.

Critical contraindications

The list of contraindications related to the vasodilating effect is strict.

• Interaction with Nitrates: Absolutely forbidden! Taking Udenafil with any form of organic nitrates (Nitroglycerin) or nitric oxide donors ("poppers") causes a life-threatening drop in blood pressure.

• Severe Cardiovascular Diseases: Recent heart attack or stroke (within 6 months), unstable angina, severe heart failure.

• Blood Pressure: Persistent hypotension (pressure < 90/50 mmHg) or uncontrolled hypertension.

• Liver and Kidneys: Severe hepatic or renal failure.

• Eyes: Hereditary degenerative retinal diseases (retinitis pigmentosa).

Side effects of Udenafil (100 mg)

Udenafil at the 100 mg dose is generally well-tolerated.

• Common: Headache (the most frequent effect), facial flushing, nasal congestion.

• Less Common: Dyspepsia (indigestion), dizziness.

• Specific: Udenafil has a very low risk of the color vision disturbances (characteristic of Sildenafil) and back pain (characteristic of Tadalafil).

Immediate medical attention is required for: An erection that lasts longer than 4 hours (priapism), or sudden loss of vision/hearing.

Professional advice on using

1. Flexibility: Udenafil 100 mg is ideal for those who do not want to plan intercourse by the hour. The duration of action up to 24 hours ensures maximum flexibility.

2. Hydration: To minimize headaches, drinking enough water on the day of intake is recommended.

3. Not for daily use: The drug is intended for "on-demand" use.

Udenafil: Extended Q&A section

• How long does Udenafil last? The erection effect lasts up to 24 hours.

• What is the difference between Udenafil (100 mg) and Tadalafil (20 mg)? The main difference is duration. Tadalafil acts for up to 36 hours; Udenafil – up to 24 hours. However, Udenafil causes back pain and myalgia significantly less frequently than Tadalafil.

• What should I do if 100 mg did not work? Ensure you took the drug 30–60 minutes prior and that there was sufficient sexual stimulation. If the effect is insufficient, consult your doctor about switching to 200 mg.

• Does Udenafil prolong sexual intercourse? No. Udenafil is intended only for ED treatment and does not affect the time to ejaculation.