PULMOPRES 20

In contrast to medications for erectile dysfunction (ED), PULMOPRES is a specialized drug containing Sildenafil that is used in cardiology and pulmonology. It is indicated for the treatment of Pulmonary Arterial Hypertension (PAH). This is a serious disease characterized by high blood pressure in the pulmonary arteries.

What is PULMOPRES?

PULMOPRES is an oral medication that contains the active substance Sildenafil Citrate, but in dosages specific for PAH treatment (typically 20 mg).

1. Differentiation from ED use

Although PULMOPRES and Viagra contain the same active ingredient, their indication and dosing regimen are different:

• For ED: The drug is taken "on demand" in doses of 25–100 mg.

• For PAH: PULMOPRES is taken regularly, usually three times a day (20 mg three times daily), to maintain a stable concentration in the blood and continuously reduce pulmonary pressure.

2. Target Audience

PULMOPRES is indicated for patients with PAH (WHO Group II and III classification) to improve exercise tolerance and slow down disease progression.

Detailed mechanism of action of PULMOPRES in the lungs

The mechanism of action of PULMOPRES is based on its role as a PDE5 inhibitor, but the focus of action is shifted to the pulmonary circulation.

1. Vasoconstriction in PAH: Pulmonary hypertension is caused by the narrowing (vasoconstriction) of the pulmonary arteries, which makes it difficult for blood to pass through the lungs and increases pressure, overloading the right ventricle of the heart.

2. Action of Sildenafil: Sildenafil in PULMOPRES highly effectively blocks the PDE5 enzyme. In the pulmonary vessels, this leads to the accumulation of cGMP.

3. Vasodilation: Increased cGMP levels cause the relaxation of the smooth muscles in the walls of the pulmonary arteries, leading to their widening (vasodilation).

4. Result: Pulmonary vascular resistance is reduced, the work of the right ventricle is eased, and blood flow to the lungs for oxygenation is improved.

Key takeaway: Regular intake of PULMOPRES not only improves the quality of life but is also an essential component of the pathogenetic therapy for PAH.

Instructions for using PULMOPRES (20 mg)

The intake of PULMOPRES must be strictly monitored by a cardiologist or pulmonologist.

1. Dosage and regimen

• Standard Dose: 20 mg three times a day (every 8 hours).

• Maximum: The 20 mg dose taken three times a day is standard and should not be exceeded without specific medical instruction.

• Method: The tablet should be swallowed whole with water, regardless of food intake.

• Regularity: The medication must be taken at equal intervals to maintain a stable concentration in the blood.

2. Missed dose

If a dose is missed, it should be taken as soon as remembered, but do not take two doses at once. Continue the usual schedule thereafter.

Critical contraindications for PULMOPRES

Contraindications for PULMOPRES (Sildenafil) are strict, especially given that the drug is taken by patients with serious cardiovascular impairments.

• Interaction with Nitrates: It is absolutely forbidden to take PULMOPRES with any form of organic nitrates (Nitroglycerin) or nitric oxide donors. This combination causes a critical, life-threatening drop in systemic blood pressure.

• Concomitant Drugs: Simultaneous use with other PDE5 inhibitors (e.g., Tadalafil, Vardenafil) is prohibited.

• Severe Conditions: Severe hepatic impairment, recent heart attack or stroke, certain hereditary retinal diseases.

Side effects of PULMOPRES

Side effects are often a result of the systemic vasodilatory action.

• Very Common: Headache (the most frequent effect, especially at the start of therapy), facial flushing.

• Common: Dyspepsia (indigestion), nasal congestion, pain in the limbs.

• Less Common: Visual disturbances (temporary color perception changes), dizziness.

Professional advice on using PULMOPRES

1. Do Not Stop Taking: Discontinuing PULMOPRES can lead to a rapid increase in pulmonary pressure, which is extremely dangerous. Follow your doctor's instructions strictly.

2. BP Monitoring: Regularly monitor your systemic blood pressure, especially at the start of therapy, to avoid hypotension.

3. Dosing Flexibility: If you experience severe headaches, discuss with your doctor the possibility of temporarily reducing the dose or switching to an alternative regimen.

PULMOPRES: Extended Q&A section

• Is PULMOPRES the same as Viagra? No. Both contain Sildenafil, but PULMOPRES is used for PAH, is taken three times a day, and in a strictly set 20 mg dose. Viagra (or generics) are used for ED and are taken "on demand."

• Does PULMOPRES prolong sexual intercourse? PULMOPRES contains Sildenafil and, therefore, may improve erection. However, its main purpose and dosing regimen (three times daily) are not related to sexual function. The drug should not be used for ED treatment without a doctor's consultation, as its constant dosing regimen may be excessive and potentially dangerous for healthy individuals.

• How quickly does PULMOPRES start reducing lung pressure? The initial vasodilatory effect begins within 30–60 minutes. But a stable therapeutic effect, which manifests as improved exercise tolerance, is achieved only with regular course intake.

• Can PULMOPRES cure pulmonary hypertension? No. As of today, PAH is considered an incurable disease. PULMOPRES is a drug used to control symptoms, slow progression, and improve the quality of life.