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"Female Tadalafil" (Tadalafil): Review and mechanism of action

"Female Tadalafil" is a popular name for medications containing Tadalafil (usually 10 mg or 20 mg), which are used "off-label" to treat female sexual arousal disorder (FSAD). Tadalafil is the active ingredient in the original Tadalafil and is known for its unique duration of action—up to 36 hours.

What is "Female Tadalafil" and its purpose?

"Female Tadalafil" is a generic Tadalafil (e.g., Tadadel FM, Tadalista, Tadacip). It is important to understand that this drug is not intended to increase libido (desire), but to improve the physiological response to sexual stimulation.

1. Indication and advantages

The drug is intended for women who:

  • Experience sexual desire but have difficulty achieving physical arousal.

  • Suffer from insufficient natural lubrication.

  • Experience reduced sensitivity in erogenous zones, making orgasm difficult to achieve.

The main advantage of Tadalafil is its duration (up to 36 hours), which provides unparalleled spontaneity and eliminates the need to plan the pill intake immediately before the act.

Detailed mechanism of action of Tadalafil in women

The mechanism of action of "Female Tadalafil" is based on Tadalafil being a selective inhibitor of the PDE5 enzyme.

  1. Trigger: Sexual stimulation (thoughts, touch) causes the release of nitric oxide (NO) in the genital area.

  2. cGMP Cycle: NO stimulates the formation of cyclic GMP (cGMP), which relaxes the smooth muscles of blood vessels.

  3. PDE5 Blockade: Tadalafil blocks the PDE5 enzyme that degrades cGMP. This allows cGMP to accumulate and act longer.

  4. Result in Women:

    • Enhanced Engorgement: Blood flow to the clitoris and labia minora increases.

    • Increased Sensitivity: Swelling of the clitoris and erogenous zones makes them more sensitive to stimulation.

    • Improved Lubrication: Increased blood flow to the vaginal mucosa promotes better natural lubrication.

Key takeaway: "Female Tadalafil" is not an aphrodisiac and does not treat low libido. It improves the physiological response when sexual desire is already present.

Instructions for using "Female Tadalafil" (20 mg)

Strict adherence to the instructions is necessary, considering the high dosage and long duration of action.

1. Dosage and timing of intake

  • Dosage: 20 mg (one tablet) – is the maximum recommended daily dose for "on-demand" use.

  • Frequency of Intake: It is strictly prohibited to take more than one tablet within 24–36 hours.

  • Initial Dose: If you are trying Tadalafil for the first time, it is recommended to start with 10 mg (half a tablet).

  • Method: Swallow the tablet whole with water.

  • Timing: Take 30–60 minutes before planned sexual activity.

2. Influence of food and alcohol

  • Food: Tadalafil can be taken regardless of food intake, including moderately fatty food, which is its advantage.

  • Alcohol: Tadalafil is considered the most alcohol-friendly drug in its class. Moderate alcohol consumption usually does not reduce efficacy.

Critical contraindications

The list of contraindications related to the vasodilating effect is strict.

  • Interaction with Nitrates: Absolutely forbidden! Taking Tadalafil with any form of organic nitrates (Nitroglycerin) or nitric oxide donors ("poppers") causes a life-threatening drop in blood pressure.

  • Pregnancy and Lactation: The drug is not intended for use by pregnant or breastfeeding women.

  • Severe Cardiovascular Diseases: Recent heart attack or stroke, severe heart failure, unstable angina.

  • Blood Pressure: Persistent hypotension (pressure < 90/50 mmHg) or uncontrolled hypertension.

  • Liver and Kidneys: Severe hepatic or renal failure.

Side effects of "Female Tadalafil"

Tadalafil 20 mg is well-tolerated but has its unique set of side effects.

  • Common: Headache, dyspepsia (indigestion), facial flushing, nasal congestion.

  • Specific to Tadalafil: Back pain and myalgia (muscle aches). These effects are usually mild and pass within 12–24 hours.

  • Visual Risk: Tadalafil rarely causes color vision disturbances ("blue haze"), unlike Sildenafil.

Professional advice on using

  1. Duration is the key factor: "Female Tadalafil" is ideal for women who want prolonged support (up to 36 hours) for their physiological response, rather than the rapid, short effect of Sildenafil.

  2. Dosing Flexibility: Start with half a tablet (10 mg) to assess tolerability. If this dose is sufficient, there is no need to take 20 mg.

  3. Not for Libido Treatment: If the primary problem is a lack of sexual desire, "Female Tadalafil" will not help. In this case, a doctor should be consulted to consider other options, such as Flibanserin.

"Female Tadalafil": Extended Q&A section

  • How does "Female Tadalafil" differ from "Female Viagra"? The main difference is duration. "Female Viagra" (Sildenafil) lasts 4–6 hours, while "Female Tadalafil" (Tadalafil) lasts up to 36 hours.

  • How long does the drug last? The effect lasts up to 36 hours.

  • Can I take "Female Tadalafil" if I don't have arousal problems? The drug is intended only for the treatment of FSAD (female sexual arousal disorder). Intake without indication can lead to unnecessary side effects.

  • Will "Female Tadalafil" help me reach orgasm? Indirectly, yes. By increasing blood flow and sensitivity, the drug can make it easier to achieve orgasm with adequate stimulation, but it does not guarantee it.

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